{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dang Cao TL"],"funding":["MEXT | Japan Society for the Promotion of Science","MEXT | Japan Science and Technology Agency (JST)","MEXT | Japan Society for the Promotion of Science (JSPS)","Ministry of Education, Culture, Sports, Science and Technology","Ministry of Education, Culture, Sports, Science and Technology (MEXT)","MEXT | Japan Science and Technology Agency"],"pagination":["e2503081122"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12435292"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["122(36)"],"pubmed_abstract":["Metastasis remains the leading cause of cancer-related mortality, driven by complex interactions within the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) play a pivotal role in metastatic progression, yet their molecular diversity and upstream regulators remain poorly defined. Glycoprotein nonmetastatic melanoma protein B (GPNMB), overexpressed in subsets of tumors including triple-negative breast cancer (TNBC), is implicated in epithelial-mesenchymal transition (EMT) and cancer stemness. Recent single-cell RNA sequencing (scRNA-seq) identified GPNMB as a marker of immunosuppressive TAMs associated with poor prognosis, but its mechanistic role in TNBC has remained unclear. Coculturing monocytic cells with three-dimensional TNBC spheres induced GPNMB<sup>+</sup> TAMs exp"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Tumor-expressed GPNMB orchestrates Siglec-9&lt;sup&gt;+&lt;/sup&gt; TAM polarization and EMT to promote metastasis in triple-negative breast cancer."],"pmcid":["PMC12435292"],"funding_grant_id":["JPMJST2052","JPMJCR20B3","JP24K02257","23H04879"],"pubmed_authors":["Watanabe Y","Kimura T","Azmi NU","Nagai-Okatani C","Dang Cao TL","Poullikkas T","Baba M","Kawanishi K","Abdelaziz M","Shiratani R","Okita Y","Kuno A","Hashimoto S","Kato M","Shigeta Y","Hengphasatporn K","Bando H","Yamazaki S"],"additional_accession":[]},"is_claimable":false,"name":"Tumor-expressed GPNMB orchestrates Siglec-9&lt;sup&gt;+&lt;/sup&gt; TAM polarization and EMT to promote metastasis in triple-negative breast cancer.","description":"Metastasis remains the leading cause of cancer-related mortality, driven by complex interactions within the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) play a pivotal role in metastatic progression, yet their molecular diversity and upstream regulators remain poorly defined. Glycoprotein nonmetastatic melanoma protein B (GPNMB), overexpressed in subsets of tumors including triple-negative breast cancer (TNBC), is implicated in epithelial-mesenchymal transition (EMT) and cancer stemness. Recent single-cell RNA sequencing (scRNA-seq) identified GPNMB as a marker of immunosuppressive TAMs associated with poor prognosis, but its mechanistic role in TNBC has remained unclear. Coculturing monocytic cells with three-dimensional TNBC spheres induced GPNMB<sup>+</sup> TAMs exp","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-07-17T01:10:10.358Z","creation":"2026-07-12T03:12:51.03Z"},"accession":"S-EPMC12435292","cross_references":{"pubmed":["40892920"],"doi":["10.1073/pnas.2503081122"]}}