biostudies-literatureUnknown22(9)Arciniegas AThe chemical analysis of the melliferous plant Viguiera dentata (Asteraceae) yielded cycloartanes 1-9 (including the new compounds 7-9), ent-kaurenes (10-15), diversifolin (16) and other constituents. The structure of 9 was confirmed by X-ray analysis. To evaluate the insecticidal potential of its constituents, in silico pesticide-likeness calculations for structures 1-16 were performed indicating no violations of the Tice rules. Tests for activity against acetylcholinesterase revealed that only cycloartanes 1 (78.85 µM) and 6 (53.54 µM) inhibited the enzyme. Molecular docking analysis showed interactions between compounds 1, 10, and 13, with Y337, a key amino acid in the catalytic site. A bioassay against Spodoptera frugiperda revealed that compounds 1, 2, 9, 10, and 13 displayed activityChemistry & biodiversitye202500917https://www.ebi.ac.uk/biostudies/studies/S-EPMC12435401biostudies-literatureNew Terpenoids from Viguiera dentata: In Silico Pesticide-Likeness Properties, Acetylcholinesterase Inhibition, Molecular Docking, and Evaluation against Spodoptera frugiperda.PMC12435401Nieto-Camacho AFigueroa-Brito RHernandez-Ortega SCastaneda-Espinoza JDPerez-Valera OVillasenor JLDelgado GArciniegas AValencia IfalseNew Terpenoids from Viguiera dentata: In Silico Pesticide-Likeness Properties, Acetylcholinesterase Inhibition, Molecular Docking, and Evaluation against Spodoptera frugiperda.The chemical analysis of the melliferous plant Viguiera dentata (Asteraceae) yielded cycloartanes 1-9 (including the new compounds 7-9), ent-kaurenes (10-15), diversifolin (16) and other constituents. The structure of 9 was confirmed by X-ray analysis. To evaluate the insecticidal potential of its constituents, in silico pesticide-likeness calculations for structures 1-16 were performed indicating no violations of the Tice rules. Tests for activity against acetylcholinesterase revealed that only cycloartanes 1 (78.85 µM) and 6 (53.54 µM) inhibited the enzyme. Molecular docking analysis showed interactions between compounds 1, 10, and 13, with Y337, a key amino acid in the catalytic site. A bioassay against Spodoptera frugiperda revealed that compounds 1, 2, 9, 10, and 13 displayed activity2025-01-01T00:00:00Z2025 Sep2026-06-01T15:45:38.869Z2026-04-08T13:47:14.855ZS-EPMC124354014028633710.1002/cbdv.202500917