{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(12)"],"submitter":["Xu Q"],"pubmed_abstract":["<b>Background</b>: <i>N</i> <sup>6</sup>-methyladenosine (m<sup>6</sup>A) modification plays a crucial role in various physiological processes by regulating mRNA biology. However, the exact impact of m<sup>6</sup>A modification on macrophages in adipose tissues under obese settings remains to be further elucidated. <b>Methods</b>: We established macrophage-specific <i>Wtap</i>-deficient mice to explore the effects of <i>Wtap</i> on obesity and metabolic disorders induced by high-fat diet (HFD) in mice. The molecular targets were explored by MeRIP-qPCR, and the metabolomic assays were performed to detect the alteration of relevant metabolites. <b>Results</b>: Wilms tumor 1-associated protein (WTAP), one of the m<sup>6</sup>A \"writers\", was downregulated in adipose tissue macrophages (ATMs) "],"journal":["International journal of biological sciences"],"pagination":["5428-5443"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12435483"],"repository":["biostudies-literature"],"pubmed_title":["WTAP Maintains Alternative Activation of Macrophages by Promoting IDH1-Mediated α-ketoglutarate Production."],"pmcid":["PMC12435483"],"pubmed_authors":["Liu SW","Zhang J","Gong Q","Xu Q","Chen L","Yu Q","Zhang S","Zou Y","Li Y","Wang CY","Wang T","Yang P","Sun F","Luo X","Xiong F"],"additional_accession":[]},"is_claimable":false,"name":"WTAP Maintains Alternative Activation of Macrophages by Promoting IDH1-Mediated α-ketoglutarate Production.","description":"<b>Background</b>: <i>N</i> <sup>6</sup>-methyladenosine (m<sup>6</sup>A) modification plays a crucial role in various physiological processes by regulating mRNA biology. However, the exact impact of m<sup>6</sup>A modification on macrophages in adipose tissues under obese settings remains to be further elucidated. <b>Methods</b>: We established macrophage-specific <i>Wtap</i>-deficient mice to explore the effects of <i>Wtap</i> on obesity and metabolic disorders induced by high-fat diet (HFD) in mice. The molecular targets were explored by MeRIP-qPCR, and the metabolomic assays were performed to detect the alteration of relevant metabolites. <b>Results</b>: Wilms tumor 1-associated protein (WTAP), one of the m<sup>6</sup>A \"writers\", was downregulated in adipose tissue macrophages (ATMs) ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-03T02:56:36.491Z","creation":"2026-04-23T03:13:35.508Z"},"accession":"S-EPMC12435483","cross_references":{"pubmed":["40959283"],"doi":["10.7150/ijbs.115672"]}}