{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Emmanuel C"],"funding":["NHLBI NIH HHS","NINDS NIH HHS","NIH HHS"],"pagination":["1749-1758"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12435514"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["96(7)"],"pubmed_abstract":["<h4>Background</h4>Asthma and obesity are frequent outcomes among individuals born extremely preterm and are associated with decreased lifespan. Neonatal inflammation is associated with chronic neurodevelopmental disorders; however, it is less studied in association with other later childhood chronic disorders in this population.<h4>Methods</h4>Fourteen hospitals in 5 U.S. states enrolled 1506 infants born before 28 weeks of gestation in the Extremely Low Gestational Age Newborn cohort in 2004-2014. Neonatal blood spots were collected on postnatal days 1, 7, 14, 21, and 28, and used to measure 14 inflammation-related proteins. Associations were evaluated between high (top quartile) levels of proteins and two chronic health disorders at ages 10 and 15 years: physician-diagnosed asthma and o"],"journal":["Pediatric research"],"pubmed_title":["Neonatal inflammation and its association with asthma and obesity in late childhood among individuals born extremely preterm."],"pmcid":["PMC12435514"],"funding_grant_id":["U01 NS040069","UG3 OD023348","R01 HL164434","L40 HL148910","UH3 OD023348","K23 HL148394","R01 HL146818"],"pubmed_authors":["Solomon C","James B","Hunter S","Sutton D","Williams J","Haynes D","Makker K","James J","Hajdarovic S","Williams B","Bose C","Gower WA","Weiland D","Bose G","Gogcu S","Martin R","Engelke S","Klarr J","Frazier J","Schreiber M","Santana A","Nylen E","Caltrider C","Batton D","Vitaro E","Fagerman S","O'Shea TM","Williams T","Lynch E","Fichorova RN","Paneth N","Henry C","Jones E","Santos H","Cole C","Yoon G","Obeid R","Neger E","Rollins JV","Shenberger J","Rathbun J","Higginson J","Mattern K","Lanier K","Montgomery A","Boshoven W","Ehrenkranz R","Adams J","Maynard M","South AM","Ramoskaite R","Higginson A","Klein D","Wiggins S","Wilson D","Nakic E","Toner D","Ansusinha E","Gile C","Hiatt D","Christianson K","Waring K","Thompson AL","Ware J","Rohde J","Foley A","Poortenga M","Msall M","Van Marter L","Haile H","Wereszczak J","Carter I","Nolan A","Rodriquez S","Singh R","Cobb V","Pujols KH","Coster T","Peters N","Bear K","Yang N","Vaidya R","Bednarek F","Romano E","Wagner K","Kring B","Perrin E","Karna P","Jensen ET","Washington K","Sanderson K","Sakai C","Bernhardt J","Prendergast B","Warner D","Johnson J","Lenski M","Pastyrnak S","Washburn L","Perrin EM","Merk T","Emmanuel C","ELGAN-ECHO Study Investigators","Oran A","Lee YA","Fry RC","Froelich N","Powers B","Morris H","Rollins C","Venuti L","Benjamin J","Mittleman M","Martin C","Pimental M","Dolins M","Brown P","Darden-Saad N","Ma C","Miras K","Shah B","Paula S","Hallisey C"],"additional_accession":[]},"is_claimable":false,"name":"Neonatal inflammation and its association with asthma and obesity in late childhood among individuals born extremely preterm.","description":"<h4>Background</h4>Asthma and obesity are frequent outcomes among individuals born extremely preterm and are associated with decreased lifespan. Neonatal inflammation is associated with chronic neurodevelopmental disorders; however, it is less studied in association with other later childhood chronic disorders in this population.<h4>Methods</h4>Fourteen hospitals in 5 U.S. states enrolled 1506 infants born before 28 weeks of gestation in the Extremely Low Gestational Age Newborn cohort in 2004-2014. Neonatal blood spots were collected on postnatal days 1, 7, 14, 21, and 28, and used to measure 14 inflammation-related proteins. Associations were evaluated between high (top quartile) levels of proteins and two chronic health disorders at ages 10 and 15 years: physician-diagnosed asthma and o","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-06-01T14:05:34.809Z","creation":"2026-04-08T13:21:23.692Z"},"accession":"S-EPMC12435514","cross_references":{"pubmed":["38914762"],"doi":["10.1038/s41390-024-03325-x"]}}