biostudies-literatureEmmanuel CNHLBI NIH HHSNINDS NIH HHSNIH HHS1749-1758https://www.ebi.ac.uk/biostudies/studies/S-EPMC12435514biostudies-literatureUnknown96(7)<h4>Background</h4>Asthma and obesity are frequent outcomes among individuals born extremely preterm and are associated with decreased lifespan. Neonatal inflammation is associated with chronic neurodevelopmental disorders; however, it is less studied in association with other later childhood chronic disorders in this population.<h4>Methods</h4>Fourteen hospitals in 5 U.S. states enrolled 1506 infants born before 28 weeks of gestation in the Extremely Low Gestational Age Newborn cohort in 2004-2014. Neonatal blood spots were collected on postnatal days 1, 7, 14, 21, and 28, and used to measure 14 inflammation-related proteins. Associations were evaluated between high (top quartile) levels of proteins and two chronic health disorders at ages 10 and 15 years: physician-diagnosed asthma and oPediatric researchNeonatal inflammation and its association with asthma and obesity in late childhood among individuals born extremely preterm.PMC12435514U01 NS040069UG3 OD023348R01 HL164434L40 HL148910UH3 OD023348K23 HL148394R01 HL146818Solomon CJames BHunter SSutton DWilliams JHaynes DMakker KJames JHajdarovic SWilliams BBose CGower WAWeiland DBose GGogcu SMartin REngelke SKlarr JFrazier JSchreiber MSantana ANylen ECaltrider CBatton DVitaro EFagerman SO'Shea TMWilliams TLynch EFichorova RNPaneth NHenry CJones ESantos HCole CYoon GObeid RNeger ERollins JVShenberger JRathbun JHigginson JMattern KLanier KMontgomery ABoshoven WEhrenkranz RAdams JMaynard MSouth AMRamoskaite RHigginson AKlein DWiggins SWilson DNakic EToner DAnsusinha EGile CHiatt DChristianson KWaring KThompson ALWare JRohde JFoley APoortenga MMsall MVan Marter LHaile HWereszczak JCarter INolan ARodriquez SSingh RCobb VPujols KHCoster TPeters NBear KYang NVaidya RBednarek FRomano EWagner KKring BPerrin EKarna PJensen ETWashington KSanderson KSakai CBernhardt JPrendergast BWarner DJohnson JLenski MPastyrnak SWashburn LPerrin EMMerk TEmmanuel CELGAN-ECHO Study InvestigatorsOran ALee YAFry RCFroelich NPowers BMorris HRollins CVenuti LBenjamin JMittleman MMartin CPimental MDolins MBrown PDarden-Saad NMa CMiras KShah BPaula SHallisey CfalseNeonatal inflammation and its association with asthma and obesity in late childhood among individuals born extremely preterm.<h4>Background</h4>Asthma and obesity are frequent outcomes among individuals born extremely preterm and are associated with decreased lifespan. Neonatal inflammation is associated with chronic neurodevelopmental disorders; however, it is less studied in association with other later childhood chronic disorders in this population.<h4>Methods</h4>Fourteen hospitals in 5 U.S. states enrolled 1506 infants born before 28 weeks of gestation in the Extremely Low Gestational Age Newborn cohort in 2004-2014. Neonatal blood spots were collected on postnatal days 1, 7, 14, 21, and 28, and used to measure 14 inflammation-related proteins. Associations were evaluated between high (top quartile) levels of proteins and two chronic health disorders at ages 10 and 15 years: physician-diagnosed asthma and o2024-01-01T00:00:00Z2024 Dec2026-06-01T14:05:34.809Z2026-04-08T13:21:23.692ZS-EPMC124355143891476210.1038/s41390-024-03325-x