biostudies-literatureBodin JAgence Nationale de la RechercheAgence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travailindustrial companiesFrench national health insurance funde0329324https://www.ebi.ac.uk/biostudies/studies/S-EPMC12435683biostudies-literatureUnknown20(9)<h4>Objective</h4>To study the association between occupational co-exposure to biomechanical risk factors, potentially neurotoxic chemicals and carpal tunnel syndrome (CTS) in a large cohort of French workers, using two methods to estimate chemical exposure: job-exposure matrices (JEM) and self-reported exposure.<h4>Methods</h4>A randomly selected sample of adults were included between 2012 and 2018 in the French cohort CONSTANCES. Self-reported CTS was assessed using the first self-administered follow-up questionnaire, sent out approximately one year after baseline. Occupational exposure to biomechanical risk factors was assessed using self-administered questionnaire completed at inclusion. Lifetime occupational exposure to chemicals was assessed using two different methods: with JEMs andPloS oneCarpal tunnel syndrome and occupational co-exposure to biomechanical factors and neurotoxic chemicals using job-exposure matrices and self-reported exposure: Findings from the Constances cohort.PMC12435683ANSES-21-EST-030ANR-11-INBS-0002Bodin JBonvallot NGilbert FDescatha AFadel MRapicault CEvanoff BGoldberg MRoquelaure YZins MfalseCarpal tunnel syndrome and occupational co-exposure to biomechanical factors and neurotoxic chemicals using job-exposure matrices and self-reported exposure: Findings from the Constances cohort.<h4>Objective</h4>To study the association between occupational co-exposure to biomechanical risk factors, potentially neurotoxic chemicals and carpal tunnel syndrome (CTS) in a large cohort of French workers, using two methods to estimate chemical exposure: job-exposure matrices (JEM) and self-reported exposure.<h4>Methods</h4>A randomly selected sample of adults were included between 2012 and 2018 in the French cohort CONSTANCES. Self-reported CTS was assessed using the first self-administered follow-up questionnaire, sent out approximately one year after baseline. Occupational exposure to biomechanical risk factors was assessed using self-administered questionnaire completed at inclusion. Lifetime occupational exposure to chemicals was assessed using two different methods: with JEMs and2025-01-01T00:00:00Z20252026-04-08T19:55:20.425Z2026-04-08T14:36:26.153ZS-EPMC124356834095300510.1371/journal.pone.0329324