{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sniffen SE"],"funding":["NIDA NIH HHS","NIDCD NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA)","U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS)","U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD)","NINDS NIH HHS","U.S. Department of Health & Human Services | National Institutes of Health (NIH)"],"pagination":["4801-4814"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12436152"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(10)"],"pubmed_abstract":["Distinct basolateral amygdala (BLA) cell populations influence emotions in manners thought important for anxiety and anxiety disorders. The BLA contains numerous cell types which can broadcast information into structures that may elicit changes in emotional states and behaviors. BLA excitatory neurons can be divided into two main classes, one of which expresses Ppp1r1b (encoding protein phosphatase 1 regulatory inhibitor subunit 1B) which is downstream of the genes encoding the D1 and D2 dopamine receptors (Drd1 and Drd2 respectively). The role of Drd1+ or Drd2+ BLA neurons in learned and unlearned emotional responses is unknown. Here, we identified that the Drd1+ and Drd2+ BLA neuron populations form two parallel pathways for communication with the ventral striatum. These neurons arise from the basal nucleus of the BLA, innervate the entire space of the ventral striatum, and are capable of exciting ventral striatum neurons. Further, through two separate behavioral assays, we found that the Drd1+ and Drd2+ parallel pathways distinctly influence both learned and unlearned emotional states when they are activated or suppressed and do so depending upon where they synapse in the ventral striatum - with unique contributions of Drd1+ and Drd2+ circuitry on negative emotional states. Overall, these results contribute to a model whereby parallel, genetically-distinct BLA to ventral striatum circuits inform emotional states in a projection-specific manner."],"journal":["Molecular psychiatry"],"pubmed_title":["Directing negative emotional states through parallel genetically-distinct basolateral amygdala pathways to ventral striatum subregions."],"pmcid":["PMC12436152"],"funding_grant_id":["R01 DA049545","R01 DA049449","R01 DC014443","R01NS117061","R34DA059718","T32 DC015994","R01 NS117061","F31 DC020364","T32015994","R01DA049449","F31DC020364","R21 DC019193","R01DA049545","F31 DC021888","DC019193","R01DC014443","R34 DA059718","F31DC021888","T32DC015994","R01 DC016519"],"pubmed_authors":["Sniffen SE","Janke E","Ma M","Thomas ER","Ryu SE","Skates GM","Johnson NL","Kokoska MM","Bhattarai J","Chavez AA","Iaconis SR","Zhang YF","Wesson DW","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"Directing negative emotional states through parallel genetically-distinct basolateral amygdala pathways to ventral striatum subregions.","description":"Distinct basolateral amygdala (BLA) cell populations influence emotions in manners thought important for anxiety and anxiety disorders. The BLA contains numerous cell types which can broadcast information into structures that may elicit changes in emotional states and behaviors. BLA excitatory neurons can be divided into two main classes, one of which expresses Ppp1r1b (encoding protein phosphatase 1 regulatory inhibitor subunit 1B) which is downstream of the genes encoding the D1 and D2 dopamine receptors (Drd1 and Drd2 respectively). The role of Drd1+ or Drd2+ BLA neurons in learned and unlearned emotional responses is unknown. Here, we identified that the Drd1+ and Drd2+ BLA neuron populations form two parallel pathways for communication with the ventral striatum. These neurons arise from the basal nucleus of the BLA, innervate the entire space of the ventral striatum, and are capable of exciting ventral striatum neurons. Further, through two separate behavioral assays, we found that the Drd1+ and Drd2+ parallel pathways distinctly influence both learned and unlearned emotional states when they are activated or suppressed and do so depending upon where they synapse in the ventral striatum - with unique contributions of Drd1+ and Drd2+ circuitry on negative emotional states. Overall, these results contribute to a model whereby parallel, genetically-distinct BLA to ventral striatum circuits inform emotional states in a projection-specific manner.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-03T03:00:51.119Z","creation":"2026-04-23T03:13:44.876Z"},"accession":"S-EPMC12436152","cross_references":{"pubmed":["40514388"],"doi":["10.1038/s41380-025-03075-0"]}}