biostudies-literatureUnknown16Su Y<h4>Objectives</h4>This systematic review aimed to evaluate the clinical efficacy and safety of Taohe Chengqi (THCQ) decoction as an adjuvant therapy for sepsis, and to provide evidence for clinical practice.<h4>Methods</h4>Eight databases were systematically searched from inception until June 2024. The study included randomized controlled trials (RCTs) involving sepsis patients, where THCQ was used as an adjunctive therapy alongside conventional treatments. The primary outcome assessed was 28-day mortality rates, secondary outcomes included severity scores, inflammatory and coagulation markers, and adverse events. Two authors independently conducted the literature screening, data extraction, and evaluation of methodological quality. Meta-analysis was performed using RevMan 5.4.1 and StataFrontiers in pharmacology1499280https://www.ebi.ac.uk/biostudies/studies/S-EPMC12436689biostudies-literatureClassical formula Taohe Chengqi decoction as an adjuvant therapy for sepsis - a systematic review and meta-analysis of randomized controlled trials.PMC12436689Liu XBu ZKong LLiu JSu RXiao XShen CWang XSu YfalseClassical formula Taohe Chengqi decoction as an adjuvant therapy for sepsis - a systematic review and meta-analysis of randomized controlled trials.<h4>Objectives</h4>This systematic review aimed to evaluate the clinical efficacy and safety of Taohe Chengqi (THCQ) decoction as an adjuvant therapy for sepsis, and to provide evidence for clinical practice.<h4>Methods</h4>Eight databases were systematically searched from inception until June 2024. The study included randomized controlled trials (RCTs) involving sepsis patients, where THCQ was used as an adjunctive therapy alongside conventional treatments. The primary outcome assessed was 28-day mortality rates, secondary outcomes included severity scores, inflammatory and coagulation markers, and adverse events. Two authors independently conducted the literature screening, data extraction, and evaluation of methodological quality. Meta-analysis was performed using RevMan 5.4.1 and Stata2025-01-01T00:00:00Z20252026-04-08T19:51:37.698Z2026-04-08T14:35:36.349ZS-EPMC124366894096368510.3389/fphar.2025.1499280