{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Wang S"],"pubmed_abstract":["<h4>Background</h4>Evidence suggests that lipoprotein metabolism play a crucial role in Alzheimer's disease (AD). However, their involvement in late-onset AD (LOAD) remains unclear.<h4>Objective</h4>This study aimed to uncover potential associations between lipoprotein metabolism and clinical LOAD diagnosis, cognitive function, and treatment.<h4>Methods</h4>We performed a lipidomic analysis of plasma samples from 46 individuals with LOAD and 16 healthy controls to investigate the potential association between lipoprotein profiles, LOAD diagnosis and cognitive function. Then, we conducted a protein-protein interaction analysis to explore the potential therapeutic role of lipoprotein molecules in LOAD.<h4>Results</h4>Our findings revealed that ApoA2 and HDL ApoA2 may be negatively associated"],"journal":["Journal of Alzheimer's disease reports"],"pagination":["25424823251378973"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12437157"],"repository":["biostudies-literature"],"pubmed_title":["Exploration of the potential role of plasma lipoprotein molecules in late-onset Alzheimer's disease among the Chinese population."],"pmcid":["PMC12437157"],"pubmed_authors":["Li Z","Wang S","Zhao Q","Lu J","Luo G","Sun D","Wang F","Zhang S","Xu H"],"additional_accession":[]},"is_claimable":false,"name":"Exploration of the potential role of plasma lipoprotein molecules in late-onset Alzheimer's disease among the Chinese population.","description":"<h4>Background</h4>Evidence suggests that lipoprotein metabolism play a crucial role in Alzheimer's disease (AD). However, their involvement in late-onset AD (LOAD) remains unclear.<h4>Objective</h4>This study aimed to uncover potential associations between lipoprotein metabolism and clinical LOAD diagnosis, cognitive function, and treatment.<h4>Methods</h4>We performed a lipidomic analysis of plasma samples from 46 individuals with LOAD and 16 healthy controls to investigate the potential association between lipoprotein profiles, LOAD diagnosis and cognitive function. Then, we conducted a protein-protein interaction analysis to explore the potential therapeutic role of lipoprotein molecules in LOAD.<h4>Results</h4>Our findings revealed that ApoA2 and HDL ApoA2 may be negatively associated","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan-Dec","modification":"2026-06-02T05:26:36.614Z","creation":"2026-04-14T03:14:11.077Z"},"accession":"S-EPMC12437157","cross_references":{"pubmed":["40963977"],"doi":["10.1177/25424823251378973"]}}