biostudies-literatureUnknown9Wang S<h4>Background</h4>Evidence suggests that lipoprotein metabolism play a crucial role in Alzheimer's disease (AD). However, their involvement in late-onset AD (LOAD) remains unclear.<h4>Objective</h4>This study aimed to uncover potential associations between lipoprotein metabolism and clinical LOAD diagnosis, cognitive function, and treatment.<h4>Methods</h4>We performed a lipidomic analysis of plasma samples from 46 individuals with LOAD and 16 healthy controls to investigate the potential association between lipoprotein profiles, LOAD diagnosis and cognitive function. Then, we conducted a protein-protein interaction analysis to explore the potential therapeutic role of lipoprotein molecules in LOAD.<h4>Results</h4>Our findings revealed that ApoA2 and HDL ApoA2 may be negatively associatedJournal of Alzheimer's disease reports25424823251378973https://www.ebi.ac.uk/biostudies/studies/S-EPMC12437157biostudies-literatureExploration of the potential role of plasma lipoprotein molecules in late-onset Alzheimer's disease among the Chinese population.PMC12437157Li ZWang SZhao QLu JLuo GSun DWang FZhang SXu HfalseExploration of the potential role of plasma lipoprotein molecules in late-onset Alzheimer's disease among the Chinese population.<h4>Background</h4>Evidence suggests that lipoprotein metabolism play a crucial role in Alzheimer's disease (AD). However, their involvement in late-onset AD (LOAD) remains unclear.<h4>Objective</h4>This study aimed to uncover potential associations between lipoprotein metabolism and clinical LOAD diagnosis, cognitive function, and treatment.<h4>Methods</h4>We performed a lipidomic analysis of plasma samples from 46 individuals with LOAD and 16 healthy controls to investigate the potential association between lipoprotein profiles, LOAD diagnosis and cognitive function. Then, we conducted a protein-protein interaction analysis to explore the potential therapeutic role of lipoprotein molecules in LOAD.<h4>Results</h4>Our findings revealed that ApoA2 and HDL ApoA2 may be negatively associated2025-01-01T00:00:00Z2025 Jan-Dec2026-06-02T05:26:36.614Z2026-04-14T03:14:11.077ZS-EPMC124371574096397710.1177/25424823251378973