{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(9)"],"submitter":["Shipley J"],"pubmed_abstract":["<h4>Importance</h4>Understanding the association between pregnancy and clinical outcomes in women with moderate to severe multiple sclerosis (MS) disability is crucial for guiding family planning and management strategies.<h4>Objective</h4>To assess peripregnancy relapse activity and disability progression in women with a preconception Expanded Disability Status Scale (EDSS) score of 3 or higher.<h4>Design, setting, and participants</h4>This multicenter retrospective cohort study used data from the MSBase Registry, with clinical observations spanning 1984 through 2024. Study cohorts included pregnant women with MS with a preconception EDSS score of 3 or higher (range: 3-10, with higher scores indicating more severe MS-related disability) and propensity score-matched nonpregnant women with "],"journal":["JAMA network open"],"pagination":["e2531581"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12439057"],"repository":["biostudies-literature"],"pubmed_title":["Pregnancy-Related Disease Outcomes in Women With Moderate to Severe Multiple Sclerosis Disability."],"pmcid":["PMC12439057"],"pubmed_authors":["Pavelek Z","Alroughani R","Slee M","Kalincik T","Boggild M","Deri N","Luis Sanchez-Menoyo J","Cauchi M","Surcinelli A","D'Amico E","Karabudak R","Yamout B","Hughes S","Mohammad Baghbanian S","van der Walt A","Sas A","Van Wijmeersch B","Foschi M","Ozakbas S","Skibina OG","de Gans K","MSBase Investigator Group","Beadnall HN","J Khoury S","John NA","Houskova J","McGuigan C","Martinkova A","Shipley J","Rozsa C","Duquette P","Solaro C","Shuey N","Prat A","Laura Saladino M","Kister I","Turkoglu R","Boz C","Horakova D","Massey J","Csepany T","Mason D","Fabis-Pedrini M","Patti F","Vrech C","Chihara N","Gouider R","Aguera-Morales E","Yeh WZ","Stourac P","Ferrando BR","Barnett M","Izquierdo G","Fatih Yetkin M","Zakaria M","Spitaleri DLA","Castillo-Trivino T","Gray O","Varchova M","D'hooghe M","Butzkueven H","Antonio Cabrera-Gomez J","Rous Z","Meca-Lallana JE","Terzi M","Hodgkinson S","Ampapa R","Recmanova E","M Carroll W","Singhal B","Kuhle J","Dobos E","Guimaraes J","Etemadifar M","Garber J","Alkhaboori J","Willekens B","Vucic S","Mrabet S","Shaygannejad V","Fernandez Bolanos R","Tomassini V","Maimone D","Lugaresi A","Al-Asmi A","Libertinova J","Field D","McCombe P","Havrdova EK","Jokubaitis VG","Macdonell RAL","Naser Moghadasi A","Piroska I","Buzzard K","Oreja-Guevara C","Peterka M","Ramanathan S","Hradilek P","Yucesan C","Grammond P","Sanfilippo PG","van Pesch V","Oh J","Lapointe E","Cristiano E","Blanco Y","Di Gregorio M","Decoo D","Cartechini E","Edite Rio M","Gobbi C","Lechner-Scott J","Simu M","Roos I","Laureys G","Altintas A","Ramo-Tello C","A Hardy T","Girard M","Eichau S","Al-Harbi T","Reddel S","Grand'Maison F","Habek M","Kovacs K","Gerlach OHH","Pia Amato M","Cardenas-Robledo S","Prevost J","Shalaby N","Soysal A","G Kermode A","Petersen T","Weinstock-Guttman B","Stetkarova I","Cambron M","Grigoriadis N"],"additional_accession":[]},"is_claimable":false,"name":"Pregnancy-Related Disease Outcomes in Women With Moderate to Severe Multiple Sclerosis Disability.","description":"<h4>Importance</h4>Understanding the association between pregnancy and clinical outcomes in women with moderate to severe multiple sclerosis (MS) disability is crucial for guiding family planning and management strategies.<h4>Objective</h4>To assess peripregnancy relapse activity and disability progression in women with a preconception Expanded Disability Status Scale (EDSS) score of 3 or higher.<h4>Design, setting, and participants</h4>This multicenter retrospective cohort study used data from the MSBase Registry, with clinical observations spanning 1984 through 2024. Study cohorts included pregnant women with MS with a preconception EDSS score of 3 or higher (range: 3-10, with higher scores indicating more severe MS-related disability) and propensity score-matched nonpregnant women with ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-02T05:52:07.643Z","creation":"2026-04-14T03:14:06.55Z"},"accession":"S-EPMC12439057","cross_references":{"pubmed":["40952740"],"doi":["10.1001/jamanetworkopen.2025.31581"]}}