biostudies-literatureUnknown8(9)Shipley J<h4>Importance</h4>Understanding the association between pregnancy and clinical outcomes in women with moderate to severe multiple sclerosis (MS) disability is crucial for guiding family planning and management strategies.<h4>Objective</h4>To assess peripregnancy relapse activity and disability progression in women with a preconception Expanded Disability Status Scale (EDSS) score of 3 or higher.<h4>Design, setting, and participants</h4>This multicenter retrospective cohort study used data from the MSBase Registry, with clinical observations spanning 1984 through 2024. Study cohorts included pregnant women with MS with a preconception EDSS score of 3 or higher (range: 3-10, with higher scores indicating more severe MS-related disability) and propensity score-matched nonpregnant women with JAMA network opene2531581https://www.ebi.ac.uk/biostudies/studies/S-EPMC12439057biostudies-literaturePregnancy-Related Disease Outcomes in Women With Moderate to Severe Multiple Sclerosis Disability.PMC12439057Pavelek ZAlroughani RSlee MKalincik TBoggild MDeri NLuis Sanchez-Menoyo JCauchi MSurcinelli AD'Amico EKarabudak RYamout BHughes SMohammad Baghbanian Svan der Walt ASas AVan Wijmeersch BFoschi MOzakbas SSkibina OGde Gans KMSBase Investigator GroupBeadnall HNJ Khoury SJohn NAHouskova JMcGuigan CMartinkova AShipley JRozsa CDuquette PSolaro CShuey NPrat ALaura Saladino MKister ITurkoglu RBoz CHorakova DMassey JCsepany TMason DFabis-Pedrini MPatti FVrech CChihara NGouider RAguera-Morales EYeh WZStourac PFerrando BRBarnett MIzquierdo GFatih Yetkin MZakaria MSpitaleri DLACastillo-Trivino TGray OVarchova MD'hooghe MButzkueven HAntonio Cabrera-Gomez JRous ZMeca-Lallana JETerzi MHodgkinson SAmpapa RRecmanova EM Carroll WSinghal BKuhle JDobos EGuimaraes JEtemadifar MGarber JAlkhaboori JWillekens BVucic SMrabet SShaygannejad VFernandez Bolanos RTomassini VMaimone DLugaresi AAl-Asmi ALibertinova JField DMcCombe PHavrdova EKJokubaitis VGMacdonell RALNaser Moghadasi APiroska IBuzzard KOreja-Guevara CPeterka MRamanathan SHradilek PYucesan CGrammond PSanfilippo PGvan Pesch VOh JLapointe ECristiano EBlanco YDi Gregorio MDecoo DCartechini EEdite Rio MGobbi CLechner-Scott JSimu MRoos ILaureys GAltintas ARamo-Tello CA Hardy TGirard MEichau SAl-Harbi TReddel SGrand'Maison FHabek MKovacs KGerlach OHHPia Amato MCardenas-Robledo SPrevost JShalaby NSoysal AG Kermode APetersen TWeinstock-Guttman BStetkarova ICambron MGrigoriadis NfalsePregnancy-Related Disease Outcomes in Women With Moderate to Severe Multiple Sclerosis Disability.<h4>Importance</h4>Understanding the association between pregnancy and clinical outcomes in women with moderate to severe multiple sclerosis (MS) disability is crucial for guiding family planning and management strategies.<h4>Objective</h4>To assess peripregnancy relapse activity and disability progression in women with a preconception Expanded Disability Status Scale (EDSS) score of 3 or higher.<h4>Design, setting, and participants</h4>This multicenter retrospective cohort study used data from the MSBase Registry, with clinical observations spanning 1984 through 2024. Study cohorts included pregnant women with MS with a preconception EDSS score of 3 or higher (range: 3-10, with higher scores indicating more severe MS-related disability) and propensity score-matched nonpregnant women with 2025-01-01T00:00:00Z2025 Sep2026-06-02T05:52:07.643Z2026-04-14T03:14:06.55ZS-EPMC124390574095274010.1001/jamanetworkopen.2025.31581