biostudies-literatureUnknownBarr EANational Institute of Allergy and Infectious DiseasesEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNIAID NIH HHS<i>Background:</i> Primary results of the International Maternal Pediatric Adolescent AIDS Clinical Trials Network (IMPAACT) 2002 trial showed that cognitive behavioural therapy (CBT) and medication management algorithm (MMA) (COMB-R) significantly improved depression in youth with HIV (YWH) compared with enhanced standard care (ESC). Acceptability and satisfaction were examined among study participants and clinicians.<i>Method:</i> Between March 2017 and March 2019, 13 U.S. sites enrolled YWH, aged 12-24, diagnosed with nonpsychotic depression. Sites were randomised to either COMB-R (CBT by a therapist and licensed prescriber) or ESC (standard psychotherapy and medication management). After the intervention (week 24), participants, prescribers, and therapists rated acceptability and satisJournal of child and adolescent mental health1-16https://www.ebi.ac.uk/biostudies/studies/S-EPMC12439113biostudies-literatureParticipant acceptability and clinician satisfaction of cognitive behavioural therapy and medication management algorithm compared with enhanced standard care for treatment of depression among youth with HIV.PMC12439113UM1 AI068632UM1 AI106716P30 AI042853HHSN275201800001IUM1 AI068616UM1AI068616-15 (IMPAACT SDMC)Townley EBarr EAKennard BDEmslie GJKnowles KBuisson SDeville JGShapiro DEBergam LShikora MBrown LKKrotje CGillespie SLBaltrusaitis KfalseParticipant acceptability and clinician satisfaction of cognitive behavioural therapy and medication management algorithm compared with enhanced standard care for treatment of depression among youth with HIV.<i>Background:</i> Primary results of the International Maternal Pediatric Adolescent AIDS Clinical Trials Network (IMPAACT) 2002 trial showed that cognitive behavioural therapy (CBT) and medication management algorithm (MMA) (COMB-R) significantly improved depression in youth with HIV (YWH) compared with enhanced standard care (ESC). Acceptability and satisfaction were examined among study participants and clinicians.<i>Method:</i> Between March 2017 and March 2019, 13 U.S. sites enrolled YWH, aged 12-24, diagnosed with nonpsychotic depression. Sites were randomised to either COMB-R (CBT by a therapist and licensed prescriber) or ESC (standard psychotherapy and medication management). After the intervention (week 24), participants, prescribers, and therapists rated acceptability and satis2024-01-01T00:00:00Z2024 Nov2026-06-01T15:49:26.975Z2026-04-08T13:49:00.8ZS-EPMC124391133955075810.2989/17280583.2024.2387632