{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Obura B"],"funding":["Wellcome Trust"],"pagination":["1504-1514"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12439288"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(9)"],"pubmed_abstract":["Early onset neonatal Group B Streptococcus (GBS) infection accounts for significant global morbidity and mortality. Intrapartum prophylaxis with benzylpenicillin is advised for women at high risk of having a baby affected by early onset GBS disease. Pregnancy-related physiological changes can alter pharmacokinetics. To estimate the intrapartum pharmacokinetics of penicillin, women (n = 12) at risk of GBS disease were enrolled. A fixed regimen of intravenous benzylpenicillin 3 g at onset of labor and 1.5 g every 4 h until delivery was used. Benzylpenicillin concentrations in plasma and umbilical cord were quantified. A nonparametric population pharmacokinetic model was fitted to the data and regimens that optimized drug exposure (fC<sub>min</sub> > MIC for 100% of the dosing interval) were "],"journal":["CPT: pharmacometrics & systems pharmacology"],"pubmed_title":["Pharmacokinetics of Intrapartum Benzylpenicillin: Insights Into Candidate Regimens to Prevent Early Onset Neonatal Group B Streptococcus Disease."],"pmcid":["PMC12439288"],"funding_grant_id":["226691/Z/22/Z"],"pubmed_authors":["Jimenez-Valverde A","Waitt C","Unsworth J","Das S","Obura B","Hope W","Navaratnam K"],"additional_accession":[]},"is_claimable":false,"name":"Pharmacokinetics of Intrapartum Benzylpenicillin: Insights Into Candidate Regimens to Prevent Early Onset Neonatal Group B Streptococcus Disease.","description":"Early onset neonatal Group B Streptococcus (GBS) infection accounts for significant global morbidity and mortality. Intrapartum prophylaxis with benzylpenicillin is advised for women at high risk of having a baby affected by early onset GBS disease. Pregnancy-related physiological changes can alter pharmacokinetics. To estimate the intrapartum pharmacokinetics of penicillin, women (n = 12) at risk of GBS disease were enrolled. A fixed regimen of intravenous benzylpenicillin 3 g at onset of labor and 1.5 g every 4 h until delivery was used. Benzylpenicillin concentrations in plasma and umbilical cord were quantified. A nonparametric population pharmacokinetic model was fitted to the data and regimens that optimized drug exposure (fC<sub>min</sub> > MIC for 100% of the dosing interval) were ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-01T06:21:56.967Z","creation":"2026-04-08T09:46:16.488Z"},"accession":"S-EPMC12439288","cross_references":{"pubmed":["40629558"],"doi":["10.1002/psp4.70072"]}}