{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dakarapu US"],"funding":["NIGMS NIH HHS"],"pagination":["14696-14702"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12439862"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(19)"],"pubmed_abstract":["Traceless acetal-directed, <i>α</i>-specific <i>syn</i>-hydrosilylation of propargyl alcohols has been developed, enabling a synthesis of <i>β</i>-silyl allylic alcohols. An introduction of inexpensive, readily accessible acetal as a traceless, two-atom tether directing group (DG), along with a <i>π</i>-acidic catalyst, facilitates the proximal, <i>α</i>-selective <i>syn</i>-hydrosilylation of a broad spectrum of primary to tertiary propargyl alcohols. Notably, the utilization of a highly fluorinated, <i>π</i>-acidic Rh(I)/P(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub> catalyst allows rapid cyclizing <i>syn</i>-addition of a silicon-metal species across a C-C triple bond via a strong M-<i>π</i> interaction. A postmodification of the resulting cyclic silyl acetal not only removes the DG, rendering it traceless, but also introduces a functional group to the silicon moiety, enhancing the versatility and utility of the products."],"journal":["ACS catalysis"],"pubmed_title":["Traceless Acetal-Directed Catalytic Hydrosilylation of Propargyl Acetates Harnessing the &lt;i&gt;π&lt;/i&gt;-Acidic Catalyst."],"pmcid":["PMC12439862"],"funding_grant_id":["R15 GM116031"],"pubmed_authors":["Das Adhikary S","Nguyen HH","Avullala T","Dakarapu US","Jeon J","Chang YC"],"additional_accession":[]},"is_claimable":false,"name":"Traceless Acetal-Directed Catalytic Hydrosilylation of Propargyl Acetates Harnessing the &lt;i&gt;π&lt;/i&gt;-Acidic Catalyst.","description":"Traceless acetal-directed, <i>α</i>-specific <i>syn</i>-hydrosilylation of propargyl alcohols has been developed, enabling a synthesis of <i>β</i>-silyl allylic alcohols. An introduction of inexpensive, readily accessible acetal as a traceless, two-atom tether directing group (DG), along with a <i>π</i>-acidic catalyst, facilitates the proximal, <i>α</i>-selective <i>syn</i>-hydrosilylation of a broad spectrum of primary to tertiary propargyl alcohols. Notably, the utilization of a highly fluorinated, <i>π</i>-acidic Rh(I)/P(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub> catalyst allows rapid cyclizing <i>syn</i>-addition of a silicon-metal species across a C-C triple bond via a strong M-<i>π</i> interaction. A postmodification of the resulting cyclic silyl acetal not only removes the DG, rendering it traceless, but also introduces a functional group to the silicon moiety, enhancing the versatility and utility of the products.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-06-01T14:04:52.748Z","creation":"2026-04-08T13:19:20.331Z"},"accession":"S-EPMC12439862","cross_references":{"pubmed":["40964169"],"doi":["10.1021/acscatal.4c04132"]}}