biostudies-literatureUnknownMuller GWe evaluated whether non-invasive estimated inspiratory muscle pressure (P_mus) predicts extubation outcomes in ICU patients. Estimated P_mus, reflecting the pressure generated by respiratory muscles, was measured before and after the spontaneous breathing trial (SBT). Lower pre-SBT estimated P_mus (<4.1 cmH₂O) and post-SBT (<4.4 cmH₂O) were associated with extubation failure (AUC ≈ 0.73). P0.1 and dynamic transpulmonary pressure (P_L,dyn) showed no significant association. Estimated P_mus offers a simple bedside method to assess inspiratory muscle strength and may help identify patients at risk of extubation failure. Further multicenter studies are needed to validate these findings.Journal of the Intensive Care Society17511437251377989https://www.ebi.ac.uk/biostudies/studies/S-EPMC12440903biostudies-literatureLower non-invasive estimated P&lt;sub&gt;mus&lt;/sub&gt; predicts extubation failure in mechanically ventilated ICU patients.PMC12440903Zocoli MBZamprogna GTMagnante JGoligher ECRatico GBdo Nascimento SAMuller GBaptistella ARfalseLower non-invasive estimated P&lt;sub&gt;mus&lt;/sub&gt; predicts extubation failure in mechanically ventilated ICU patients.We evaluated whether non-invasive estimated inspiratory muscle pressure (P_mus) predicts extubation outcomes in ICU patients. Estimated P_mus, reflecting the pressure generated by respiratory muscles, was measured before and after the spontaneous breathing trial (SBT). Lower pre-SBT estimated P_mus (<4.1 cmH₂O) and post-SBT (<4.4 cmH₂O) were associated with extubation failure (AUC ≈ 0.73). P0.1 and dynamic transpulmonary pressure (P_L,dyn) showed no significant association. Estimated P_mus offers a simple bedside method to assess inspiratory muscle strength and may help identify patients at risk of extubation failure. Further multicenter studies are needed to validate these findings.2025-01-01T00:00:00Z2025 Sep2026-06-03T12:06:49.419Z2026-04-27T03:11:32.927ZS-EPMC124409034096919510.1177/17511437251377989