{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7"],"submitter":["Shah VV"],"pubmed_abstract":["<h4>Background</h4>Recent findings suggest that a single gait assessment in a clinic may not reflect everyday mobility.<h4>Objective</h4>We compared gait measures that best differentiated individuals with spinocerebellar ataxia (SCA) from age-matched healthy controls (HC) during a supervised gait test in the clinic vs. a week of unsupervised gait during daily life.<h4>Methods</h4>Twenty-six individuals with SCA types 1, 2, 3, and 6, and 13 (HC) wore three Opal inertial sensors (on both feet and lower back) during a 2-minute walk in the clinic and for seven days in daily life. Seventeen gait measures were analyzed to investigate the group differences using Mann-Whitney <i>U</i>-tests and area under the curve (AUC).<h4>Results</h4>Ten gait measures were significantly worse in SCA than HC for the clinic test (<i>p</i> < 0.003), but only 3 were worse in daily life (<i>p</i> < 0.003). Only a few gait measures consistently discriminated groups in both environments. Specifically, variability in Swing Time and Double Support Time had AUCs of 0.99 (<i>p</i> < 0.0001) and 0.96 (<i>p</i> < 0.0001) in the clinic, and 0.84 (<i>p</i> < 0.0003) and 0.80 (<i>p</i> < 0.002) in daily life, respectively. Clinical gait measures showed stronger correlations with clinical outcomes (ie, SARA and FARS-ADL; r = 0.50-0.77) than between daily life gait measures (r = 0.31-0.49). Gait activity in daily life was not statistically significant between the SCA and HC groups (<i>p</i> > 0.06).<h4>Conclusions</h4>Digital gait measures discriminate SCA in both environments. In-clinic measures are more sensitive, while daily life measures provide ecological validity, highlighting a trade-off and offering complementary insights."],"journal":["Frontiers in digital health"],"pagination":["1590150"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12440962"],"repository":["biostudies-literature"],"pubmed_title":["Clinic vs. daily life gait characteristics in patients with spinocerebellar ataxia."],"pmcid":["PMC12440962"],"pubmed_authors":["Sowalsky K","Safarpour D","Jagodinsky A","Carlson-Kuhta P","Shah VV","El-Gohary M","McNames J","Casey H","Muzyka D","Gomez CM","Horak FB"],"additional_accession":[]},"is_claimable":false,"name":"Clinic vs. daily life gait characteristics in patients with spinocerebellar ataxia.","description":"<h4>Background</h4>Recent findings suggest that a single gait assessment in a clinic may not reflect everyday mobility.<h4>Objective</h4>We compared gait measures that best differentiated individuals with spinocerebellar ataxia (SCA) from age-matched healthy controls (HC) during a supervised gait test in the clinic vs. a week of unsupervised gait during daily life.<h4>Methods</h4>Twenty-six individuals with SCA types 1, 2, 3, and 6, and 13 (HC) wore three Opal inertial sensors (on both feet and lower back) during a 2-minute walk in the clinic and for seven days in daily life. Seventeen gait measures were analyzed to investigate the group differences using Mann-Whitney <i>U</i>-tests and area under the curve (AUC).<h4>Results</h4>Ten gait measures were significantly worse in SCA than HC for the clinic test (<i>p</i> < 0.003), but only 3 were worse in daily life (<i>p</i> < 0.003). Only a few gait measures consistently discriminated groups in both environments. Specifically, variability in Swing Time and Double Support Time had AUCs of 0.99 (<i>p</i> < 0.0001) and 0.96 (<i>p</i> < 0.0001) in the clinic, and 0.84 (<i>p</i> < 0.0003) and 0.80 (<i>p</i> < 0.002) in daily life, respectively. Clinical gait measures showed stronger correlations with clinical outcomes (ie, SARA and FARS-ADL; r = 0.50-0.77) than between daily life gait measures (r = 0.31-0.49). Gait activity in daily life was not statistically significant between the SCA and HC groups (<i>p</i> > 0.06).<h4>Conclusions</h4>Digital gait measures discriminate SCA in both environments. In-clinic measures are more sensitive, while daily life measures provide ecological validity, highlighting a trade-off and offering complementary insights.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-03T12:06:50.981Z","creation":"2026-04-27T03:11:32.53Z"},"accession":"S-EPMC12440962","cross_references":{"pubmed":["40970140"],"doi":["10.3389/fdgth.2025.1590150"]}}