{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["71(4)"],"submitter":["Handoh T"],"pubmed_abstract":["<h4>Objectives</h4>Dilated cardiomyopathy (DCM) is one of the leading causes of heart failure. To date, 48 genes are known to be associated with DCM. Telethonin, encoded by the <i>TCAP</i> gene, is a Z-disk protein that composes cytoskeletal structures and facilitates various signaling pathways in cardiomyocytes. At least, six <i>TCAP</i> variants have been found in patients with DCM. We sought to investigate the role of <i>TCAP</i> in cardiac function using <i>TCAP</i>-knockdown (KD) iPS cell (iPSC)-induced cardiomyocytes (CMs).<h4>Methods & results</h4>To investigate the role of <i>TCAP</i> in cardiomyocytes, the <i>TCAP</i> gene was knocked down in human iPS cells established from a healthy subject (201B7) using the CRISPR-Cas9 genome editing. The expressions of <i>TCAP</i> mRNA and tel"],"journal":["Juntendo medical journal"],"pagination":["247-255"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12441175"],"repository":["biostudies-literature"],"pubmed_title":["Knockdown of Telethonin Reduces Contractions and Provokes Aberrant Ca&lt;sup&gt;2+&lt;/sup&gt;-waves in Human iPS Cell-induced Cardiomyocytes."],"pmcid":["PMC12441175"],"pubmed_authors":["Hori A","Ai T","Inaba H","Yamamoto H","Horiuchi Y","Tabe Y","Handoh T","Turker I","Miida T"],"additional_accession":[]},"is_claimable":false,"name":"Knockdown of Telethonin Reduces Contractions and Provokes Aberrant Ca&lt;sup&gt;2+&lt;/sup&gt;-waves in Human iPS Cell-induced Cardiomyocytes.","description":"<h4>Objectives</h4>Dilated cardiomyopathy (DCM) is one of the leading causes of heart failure. To date, 48 genes are known to be associated with DCM. Telethonin, encoded by the <i>TCAP</i> gene, is a Z-disk protein that composes cytoskeletal structures and facilitates various signaling pathways in cardiomyocytes. At least, six <i>TCAP</i> variants have been found in patients with DCM. We sought to investigate the role of <i>TCAP</i> in cardiac function using <i>TCAP</i>-knockdown (KD) iPS cell (iPSC)-induced cardiomyocytes (CMs).<h4>Methods & results</h4>To investigate the role of <i>TCAP</i> in cardiomyocytes, the <i>TCAP</i> gene was knocked down in human iPS cells established from a healthy subject (201B7) using the CRISPR-Cas9 genome editing. The expressions of <i>TCAP</i> mRNA and tel","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-04-27T03:17:14.125Z","creation":"2026-04-27T03:11:10.475Z"},"accession":"S-EPMC12441175","cross_references":{"pubmed":["40969822"],"doi":["10.14789/ejmj.JMJ24-0025-OA"]}}