{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cleary JA"],"funding":["NIA NIH HHS","Nancy and Buster Alvord Endowment"],"pagination":["e70597"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12441806"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(9)"],"pubmed_abstract":["<h4>Introduction</h4>Brain insulin resistance (bIR) is a risk factor for Alzheimer's disease (AD). However, the association between bIR and peripheral insulin resistance and their effects on cognition remains unclear.<h4>Methods</h4>Here, we analyzed the expression of key genes (n = 84) involved in insulin signaling in brain tissue collected from healthy and AD subjects, as well as regulatory microRNAs (miRNAs) in the brain tissue and tissue-derived small extracellular vesicles (sEV). Subsequently, miRNA expression was analyzed in plasma neuron-derived sEV (NDE) of a second cohort consisting of cognitively normal and adjudicated mixed dementia (aMD) subjects, all with type 2 diabetes.<h4>Results</h4>Analysis of miRNAs in brain tissue and their sEV revealed significant and concordant dysreg"],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["MicroRNA cargo in neuron-derived vesicles as peripheral biomarkers of brain insulin dysregulation."],"pmcid":["PMC12441806"],"funding_grant_id":["R01 AG061805","U24AG072458","U19AG066567","3R01AG058571-02S1","1R21 AG075611","P30AG066509","1RF1AG068629"],"pubmed_authors":["Craft S","Cleary JA","Espeland MA","Ding J","Harrison W","Hsu FC","Howard M","Deep G","Su Y","Singh S","Keene CD","Hayden KM","Kumar A"],"additional_accession":[]},"is_claimable":false,"name":"MicroRNA cargo in neuron-derived vesicles as peripheral biomarkers of brain insulin dysregulation.","description":"<h4>Introduction</h4>Brain insulin resistance (bIR) is a risk factor for Alzheimer's disease (AD). However, the association between bIR and peripheral insulin resistance and their effects on cognition remains unclear.<h4>Methods</h4>Here, we analyzed the expression of key genes (n = 84) involved in insulin signaling in brain tissue collected from healthy and AD subjects, as well as regulatory microRNAs (miRNAs) in the brain tissue and tissue-derived small extracellular vesicles (sEV). Subsequently, miRNA expression was analyzed in plasma neuron-derived sEV (NDE) of a second cohort consisting of cognitively normal and adjudicated mixed dementia (aMD) subjects, all with type 2 diabetes.<h4>Results</h4>Analysis of miRNAs in brain tissue and their sEV revealed significant and concordant dysreg","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T11:25:02.155Z","creation":"2026-04-27T03:10:27.098Z"},"accession":"S-EPMC12441806","cross_references":{"pubmed":["40960061"],"doi":["10.1002/alz.70597"]}}