{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(9)"],"submitter":["Sia J"],"pubmed_abstract":["<h4>Importance</h4>Risk-reducing early-salpingectomy (RRES) and delayed oophorectomy (DO) is a novel 2-stage alternative prevention strategy to risk-reducing salpingo-oophorectomy (RRSO) that avoids detrimental consequences of premature menopause. However, direct data on the clinical effectiveness for ovarian cancer (OC) risk reduction are lacking.<h4>Objective</h4>To explore how to define clinical effectiveness from prospective cohort studies using the estimand framework and sample size requirements.<h4>Design, setting, and participants</h4>In this comparative effectiveness research study, estimand and analysis options were considered to evaluate the clinical effectiveness of RRES with DO by extending the UK PROTECTOR cohort study, a multicenter, prospective, observational, national cohor"],"journal":["JAMA network open"],"pagination":["e2532195"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12441877"],"repository":["biostudies-literature"],"pubmed_title":["Estimands for Clinical Effectiveness of Risk-Reducing Early Salpingectomy in Women With High Risk of Ovarian Cancer."],"pmcid":["PMC12441877"],"pubmed_authors":["Ray I","Crosbie E","Taylor S","Povolotskaya N","Hamed H","Ahmed M","Baxter K","Chattopadhyay S","Oxley S","Duncan T","Elboraei R","Mackintosh M","Matthews N","Lane EF","Hanson H","Newton C","Willett M","Khaing TT","Reig G","Devaja O","Chalhoub T","Dalton J","Sundar S","Gurumurthy M","PROTECTOR team","Bryson G","Ohwo V","Legood R","Wei X","Harley I","Borley J","Ghaem-Maghami S","Ragupathy K","Casey L","De Souza B","Kalra A","Singh A","Faruqi A","Van Seters M","Edey K","Idahl A","Sideris M","Side L","Kamran A","Rao S","Piletska N","Iyer R","Prasad M","Saridogan E","McDermott J","Misiura H","Brady A","Fraser H","Arora R","Sasieni P","Sharma A","Ganesan R","Kaushik S","Ganesan S","Evans DG","Singh N","Barker V","Manchanda R","Kohut K","Fierheller CT","Kodiathodi S","Fegan S","Hutson R","Oktaba M","Park C","Bolton H","Snape K","Tryczynska M","Tailor A","Alazzani H","Ryan N","McArdle G","Balega J","Gnanachandran C","Mehra G","Menon U","Abdelaziz M","McCluggage WG","Sia J","Rowlands G","Phillips A","Sengupta P","Abdul B","Williamson K","O'Donnell R","Peevor R","Rosenthal A","Marks M","Sassarini J","Brentnall A","Cameron I","Pilkington T","Doh H","Mansour L","Trevisan G","Zulfiqar N","Deshmukh P"],"additional_accession":[]},"is_claimable":false,"name":"Estimands for Clinical Effectiveness of Risk-Reducing Early Salpingectomy in Women With High Risk of Ovarian Cancer.","description":"<h4>Importance</h4>Risk-reducing early-salpingectomy (RRES) and delayed oophorectomy (DO) is a novel 2-stage alternative prevention strategy to risk-reducing salpingo-oophorectomy (RRSO) that avoids detrimental consequences of premature menopause. However, direct data on the clinical effectiveness for ovarian cancer (OC) risk reduction are lacking.<h4>Objective</h4>To explore how to define clinical effectiveness from prospective cohort studies using the estimand framework and sample size requirements.<h4>Design, setting, and participants</h4>In this comparative effectiveness research study, estimand and analysis options were considered to evaluate the clinical effectiveness of RRES with DO by extending the UK PROTECTOR cohort study, a multicenter, prospective, observational, national cohor","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-07-15T06:51:33.026Z","creation":"2026-06-30T03:27:09.062Z"},"accession":"S-EPMC12441877","cross_references":{"pubmed":["40956577"],"doi":["10.1001/jamanetworkopen.2025.32195"]}}