biostudies-literatureJiang WNIDCD NIH HHSNational Institutes of HealthNIH HHSDivision of Chemical, Bioengineering, Environmental, and Transport Systems1801-1813https://www.ebi.ac.uk/biostudies/studies/S-EPMC12441979biostudies-literatureUnknown23(5)A human laryngeal model, incorporating all the cartilages and the intrinsic muscles, was reconstructed based on MRI data. The vocal fold was represented as a multilayer structure with detailed inner components. The activation levels of the thyroarytenoid (TA) and cricothyroid (CT) muscles were systematically varied from zero to full activation allowing for the analysis of their interaction and influence on vocal fold dynamics and glottal flow. The finite element method was employed to calculate the vocal fold dynamics, while the one-dimensional Bernoulli equation was utilized to calculate the glottal flow. The analysis was focused on the muscle influence on the fundamental frequency (f_o). We found that while CT and TA  activation increased the f_o in most of the conditBiomechanics and modeling in mechanobiologyA computational study of the influence of thyroarytenoid and cricothyroid muscle interaction on vocal fold dynamics in an MRI-based human laryngeal model.PMC12441979R15DC0192291652632R15 DC019229Geng BZheng XJiang WXue QfalseA computational study of the influence of thyroarytenoid and cricothyroid muscle interaction on vocal fold dynamics in an MRI-based human laryngeal model.A human laryngeal model, incorporating all the cartilages and the intrinsic muscles, was reconstructed based on MRI data. The vocal fold was represented as a multilayer structure with detailed inner components. The activation levels of the thyroarytenoid (TA) and cricothyroid (CT) muscles were systematically varied from zero to full activation allowing for the analysis of their interaction and influence on vocal fold dynamics and glottal flow. The finite element method was employed to calculate the vocal fold dynamics, while the one-dimensional Bernoulli equation was utilized to calculate the glottal flow. The analysis was focused on the muscle influence on the fundamental frequency (f_o). We found that while CT and TA  activation increased the f_o in most of the condit2024-01-01T00:00:00Z2024 Oct2026-05-29T03:11:38.892Z2026-05-29T03:06:19.152ZS-EPMC124419793898194610.1007/s10237-024-01869-9