{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen F"],"funding":["the 551 Health Talent Training Project of Health Commission of Zhejiang Province","the Research Funds of Hangzhou Institute for Advanced Study","the Joint Research Program of Eye Research Center","Natural Science Foundation of Zhejiang Province, China","the Key Research and Development Program of Zhejiang Province","National Natural Science Foundation of China","National Key Research and Development Program","the Qiantang Interdisciplinary Research Grant","National Key Research and Development Program of China"],"pagination":["e04851"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12442674"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(34)"],"pubmed_abstract":["Pyroptosis is a proinflammatory programmed cell death (PCD) that is causally linked to antitumor immune responses, but the therapeutic potential of pyroptosis has been limited by the lack of tumor-specific and controllable inducers. Here, it is reported that tumor-specific pyroptosis can be spatiotemporally triggered via near-infrared light (NIR-pyroptosis) by using an antibody-bound indocyanine green (ICG), a clinically approved and nontoxic fluorescent dye. Mechanistically, the key molecular steps are identified by which antibody-bound ICG generates excessive reactive oxygen species (ROS) within lysosomes after internalization, leading to lysosomal membrane damage and the cytosolic release of cathepsin S (CTSS), which cleaves gasdermin D (GSDMD), IL-18, and IL-1β independently of caspase"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Lysosomal Cathepsin S Escape Facilitates Near Infrared Light-Triggered Pyroptosis Via an Antibody-Indocyanine Green Conjugate."],"pmcid":["PMC12442674"],"funding_grant_id":["82202231","ERC2024014","82373782","2024HIAS-V008","T2188102","82172598","LZ22H310001","92353000","2024SDYXS0001","2023YFC3404003"],"pubmed_authors":["Shimura T","Cao J","Lu Y","Chen F","Zheng WH","Tian XF","Li XF","Guo P","Fang MY","Tan WH","Ji Q","Dai YJ","Sha CL","Chen HB","Fang JM","Yang T","Chen DY","Shang JB"],"additional_accession":[]},"is_claimable":false,"name":"Lysosomal Cathepsin S Escape Facilitates Near Infrared Light-Triggered Pyroptosis Via an Antibody-Indocyanine Green Conjugate.","description":"Pyroptosis is a proinflammatory programmed cell death (PCD) that is causally linked to antitumor immune responses, but the therapeutic potential of pyroptosis has been limited by the lack of tumor-specific and controllable inducers. Here, it is reported that tumor-specific pyroptosis can be spatiotemporally triggered via near-infrared light (NIR-pyroptosis) by using an antibody-bound indocyanine green (ICG), a clinically approved and nontoxic fluorescent dye. Mechanistically, the key molecular steps are identified by which antibody-bound ICG generates excessive reactive oxygen species (ROS) within lysosomes after internalization, leading to lysosomal membrane damage and the cytosolic release of cathepsin S (CTSS), which cleaves gasdermin D (GSDMD), IL-18, and IL-1β independently of caspase","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T12:09:24.129Z","creation":"2026-04-27T03:11:30.666Z"},"accession":"S-EPMC12442674","cross_references":{"pubmed":["40539828"],"doi":["10.1002/advs.202504851"]}}