{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(34)"],"submitter":["Lu H"],"pubmed_abstract":["Radiation therapy (RT) is essential for treating thoracic malignancies but often causes significant lung damage. FLASH-RT, an ultra-high dose rate irradiation technique, shows potential in reducing radiation-induced lung injury (RILI) while maintaining tumor control. However, the underlying immune mechanisms remain poorly understood. This study investigates the immune and cellular responses to FLASH-RT versus conventional dose rate (CONV) RT during the early phase of RILI. Using single-cell RNA sequencing (scRNA-seq), a dynamic landscape of the lung microenvironment is pictured during RILI within one-week post-irradiation. The analysis reveals that FLASH-RT induces a more immediate but transient cellular response, while CONV-RT causes sustained inflammation. FLASH irradiation significantly"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pagination":["e01797"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12442706"],"repository":["biostudies-literature"],"pubmed_title":["FLASH Irradiation Modulates Immune Responses and Accelerates Lung Recovery: A Single-Cell Perspective."],"pmcid":["PMC12442706"],"pubmed_authors":["Dong G","Quan C","Li Z","Li C","Lu H","Li D","Wang C","Liu Q","Zhang L","Li M","Xu J"],"additional_accession":[]},"is_claimable":false,"name":"FLASH Irradiation Modulates Immune Responses and Accelerates Lung Recovery: A Single-Cell Perspective.","description":"Radiation therapy (RT) is essential for treating thoracic malignancies but often causes significant lung damage. FLASH-RT, an ultra-high dose rate irradiation technique, shows potential in reducing radiation-induced lung injury (RILI) while maintaining tumor control. However, the underlying immune mechanisms remain poorly understood. This study investigates the immune and cellular responses to FLASH-RT versus conventional dose rate (CONV) RT during the early phase of RILI. Using single-cell RNA sequencing (scRNA-seq), a dynamic landscape of the lung microenvironment is pictured during RILI within one-week post-irradiation. The analysis reveals that FLASH-RT induces a more immediate but transient cellular response, while CONV-RT causes sustained inflammation. FLASH irradiation significantly","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T11:31:34.333Z","creation":"2026-04-27T03:10:25.042Z"},"accession":"S-EPMC12442706","cross_references":{"pubmed":["40536317"],"doi":["10.1002/advs.202501797"]}}