biostudies-literatureUnknown11(38)Xiong QRaising the charging voltage of a lithium||lithium cobalt oxide (Li||LiCoO₂) battery is a shortcut to realize high energy density in portable electronics, while the fragile interface of highly delithiated LiCoO₂ (>4.55 volts) can trigger the lattice oxygen release, thus leading to severe interfacial degradation and structural collapse. Here, using lithium pentadecafluorooctanoate as a fluorine source to build robust lithium fluoride-rich electrode-electrolyte interfaces, stable Li||LiCoO₂ batteries at high voltage have been realized, capable of cycling 1500, 600, and 188 times at 4.6, 4.7, and 4.8 volts, respectively. Furthermore, the practicality of Li||LiCoO₂ batteries at an unprecedented cutoff voltage of 4.8 volts has been validated by a 2.7-Science advanceseadx5020https://www.ebi.ac.uk/biostudies/studies/S-EPMC12442873biostudies-literatureA practical 4.8-V Li||LiCoO<sub>2</sub> battery.PMC12442873Zhang DFan XLi SHong HLi DWang SXiong QLiu QLi RZhi CZhang SZhu DfalseA practical 4.8-V Li||LiCoO<sub>2</sub> battery.Raising the charging voltage of a lithium||lithium cobalt oxide (Li||LiCoO₂) battery is a shortcut to realize high energy density in portable electronics, while the fragile interface of highly delithiated LiCoO₂ (>4.55 volts) can trigger the lattice oxygen release, thus leading to severe interfacial degradation and structural collapse. Here, using lithium pentadecafluorooctanoate as a fluorine source to build robust lithium fluoride-rich electrode-electrolyte interfaces, stable Li||LiCoO₂ batteries at high voltage have been realized, capable of cycling 1500, 600, and 188 times at 4.6, 4.7, and 4.8 volts, respectively. Furthermore, the practicality of Li||LiCoO₂ batteries at an unprecedented cutoff voltage of 4.8 volts has been validated by a 2.7-2025-01-01T00:00:00Z2025 Sep2026-06-03T12:10:42.011Z2026-04-27T03:11:30.657ZS-EPMC124428734096119410.1126/sciadv.adx5020