{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Niu X"],"pubmed_abstract":["<h4>Background</h4>Osteosarcoma is a primary malignant tumor, characterized by its high incidence and recurrence rate in children and adolescents. Ferroptosis, an iron-dependent form of regulated cell death, has recently been recognized as a potential therapeutic vulnerability in cancer treatment. However, its prognostic significance and underlying regulatory mechanisms in osteosarcoma remain largely unexplored.<h4>Materials and methods</h4>We constructed a prognostic model based on 12 ferroptosis-related genes using LASSO regression and validated across independent GEO cohorts (GSE21257 and GSE39055). We identified hub genes via machine learning algorithms (SVM, RF, XGBoost, BORUTA) and single-cell RNA sequencing. The exosomal transfer of COX4I2 protein from CAFs to 143B osteosarcoma cell"],"journal":["Frontiers in cell and developmental biology"],"pagination":["1620648"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12443774"],"repository":["biostudies-literature"],"pubmed_title":["Multi-transcriptomics analysis of ferroptosis related genes reveals CAFs exosomal COX4I2 as a novel therapeutic target in osteosarcoma."],"pmcid":["PMC12443774"],"pubmed_authors":["Li Z","Tian W","Zhang X","Niu X"],"additional_accession":[]},"is_claimable":false,"name":"Multi-transcriptomics analysis of ferroptosis related genes reveals CAFs exosomal COX4I2 as a novel therapeutic target in osteosarcoma.","description":"<h4>Background</h4>Osteosarcoma is a primary malignant tumor, characterized by its high incidence and recurrence rate in children and adolescents. Ferroptosis, an iron-dependent form of regulated cell death, has recently been recognized as a potential therapeutic vulnerability in cancer treatment. However, its prognostic significance and underlying regulatory mechanisms in osteosarcoma remain largely unexplored.<h4>Materials and methods</h4>We constructed a prognostic model based on 12 ferroptosis-related genes using LASSO regression and validated across independent GEO cohorts (GSE21257 and GSE39055). We identified hub genes via machine learning algorithms (SVM, RF, XGBoost, BORUTA) and single-cell RNA sequencing. The exosomal transfer of COX4I2 protein from CAFs to 143B osteosarcoma cell","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-07-15T06:51:35.391Z","creation":"2026-06-30T03:27:21.52Z"},"accession":"S-EPMC12443774","cross_references":{"pubmed":["40977891"],"doi":["10.3389/fcell.2025.1620648"]}}