biostudies-literatureBao Wthe national natural science foundation of China5471-5481https://www.ebi.ac.uk/biostudies/studies/S-EPMC12443899biostudies-literatureUnknown33(9)<h4>Background</h4>Persistent fatigue, often accompanied by neuropsychiatric symptoms (e.g., cognitive impairment, sleep disorders, depression, anxiety, and PTSD), commonly referred to as "long COVID". Fatigue is multidimensional, comprising physical, psychological, and situational components. However, the relationships between these fatigue dimensions and co-occurring neuropsychiatric symptoms remain unclear. This study aimed to (1) examine the time-varying characteristics of post-COVID fatigue and (2) determine whether specific fatigue dimensions uniquely affect neuropsychiatric symptoms in long COVID.<h4>Methods</h4>We analyzed neuropsychiatric assessments from 233 individuals at 1 and 3 months post-infection using Canonical Correlation Analysis (CCA). Participants were categorized intoInflammopharmacologyLongitudinal relationships between changes in post-COVID mental fatigue and neuropsychiatric symptoms across distinct recovery trajectories.PMC1244389982202121Li HHong NLiu JLi CZhang YXie JBao WLi PYe GChen SWang YNiu XfalseLongitudinal relationships between changes in post-COVID mental fatigue and neuropsychiatric symptoms across distinct recovery trajectories.<h4>Background</h4>Persistent fatigue, often accompanied by neuropsychiatric symptoms (e.g., cognitive impairment, sleep disorders, depression, anxiety, and PTSD), commonly referred to as "long COVID". Fatigue is multidimensional, comprising physical, psychological, and situational components. However, the relationships between these fatigue dimensions and co-occurring neuropsychiatric symptoms remain unclear. This study aimed to (1) examine the time-varying characteristics of post-COVID fatigue and (2) determine whether specific fatigue dimensions uniquely affect neuropsychiatric symptoms in long COVID.<h4>Methods</h4>We analyzed neuropsychiatric assessments from 233 individuals at 1 and 3 months post-infection using Canonical Correlation Analysis (CCA). Participants were categorized into2025-01-01T00:00:00Z2025 Sep2026-06-03T11:26:51.381Z2026-04-27T03:10:34.494ZS-EPMC124438994078999510.1007/s10787-025-01860-5