biostudies-literatureWinhusen TJNational Institute on Drug Abuse Clinical Trials NetworkEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNIDA NIH HHSUniversity of CincinnatiNational Institutes of HealthNational Institute of Child Health and Human Development112795https://www.ebi.ac.uk/biostudies/studies/S-EPMC12444429biostudies-literatureUnknown275<h4>Background</h4>Overdose is a leading cause of pregnancy-associated mortality in the US. Our personally-tailored opioid-overdose (OOD) and medication for opioid use disorder (MOUD) education intervention has been shown to significantly improve MOUD/OOD knowledge in out-of-treatment persons using illicit opioids. We evaluated the ability of the intervention modified for peripartum (pregnant or within one year postpartum) individuals, the personally-tailored OOD and MOUD education (TOME) intervention, to increase MOUD (primary) and OOD (key secondary) knowledge.<h4>Methods</h4>A six-site, two-arm, open-label, trial with 131 peripartum individuals receiving MOUD (methadone or buprenorphine) randomized to TOME, a 15-minute, computer-facilitated, individually-tailored intervention, or ControDrug and alcohol dependencePersonally-tailored opioid-overdose and medication for opioid use disorder (MOUD) education (TOME) significantly increases MOUD and overdose knowledge in peripartum individuals: Results from a randomized controlled pilot trial.PMC12444429UG1DA013720U10 DA013732UG1DA049436UG1 DA013727UG1 DA049444UG1DA049444UG1DA013727UG1 DA049436UG1 DA013732UG1DA013732UG1 DA013720Winhusen TJRosa CDilawar MKropp FCochran GKrans EELofwall MRDavies THSmid MCYoung JLLewis DHodgkins CfalsePersonally-tailored opioid-overdose and medication for opioid use disorder (MOUD) education (TOME) significantly increases MOUD and overdose knowledge in peripartum individuals: Results from a randomized controlled pilot trial.<h4>Background</h4>Overdose is a leading cause of pregnancy-associated mortality in the US. Our personally-tailored opioid-overdose (OOD) and medication for opioid use disorder (MOUD) education intervention has been shown to significantly improve MOUD/OOD knowledge in out-of-treatment persons using illicit opioids. We evaluated the ability of the intervention modified for peripartum (pregnant or within one year postpartum) individuals, the personally-tailored OOD and MOUD education (TOME) intervention, to increase MOUD (primary) and OOD (key secondary) knowledge.<h4>Methods</h4>A six-site, two-arm, open-label, trial with 131 peripartum individuals receiving MOUD (methadone or buprenorphine) randomized to TOME, a 15-minute, computer-facilitated, individually-tailored intervention, or Contro2025-01-01T00:00:00Z2025 Oct2026-06-03T15:32:14.42Z2026-06-01T03:06:08.841ZS-EPMC124444294070098710.1016/j.drugalcdep.2025.112795