{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mandal J"],"funding":["NIDDK NIH HHS","NHLBI NIH HHS"],"pagination":["1729-1742"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12444880"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["82(10)"],"pubmed_abstract":["<h4>Background</h4>Previously, we demonstrated that the ketone body, β-hydroxybutyrate, is a potent antihypertensive and reno-protective metabolite in Dahl Salt-Sensitive rats. However, the mechanism by which β-hydroxybutyrate confers these beneficial effects is understudied. Here we focused on determining whether the reno-protective effect of β-hydroxybutyrate is due to its known ability to epigenetically remodel chromatin via histone β-hydroxybutyrylation.<h4>Methods</h4>We used the same animal protocol previously used for the discovery of the reno-protective effect of β-hydroxybutyrate. Briefly, postweaning, male and female Dahl Salt-Sensitive rats were split into 2 groups and supplemented with or without 1,3-butanediol for 6 weeks. At euthanasia, circulating β-hydroxybutyrate was quant"],"journal":["Hypertension (Dallas, Tex. : 1979)"],"pubmed_title":["Epigenetic Histone β-Hydroxybutyrylation Contributes to Renoprotection by β-Hydroxybutyrate in the Dahl Rat."],"pmcid":["PMC12444880"],"funding_grant_id":["R01 HL171401","R01 DK134053","R01 HL143082"],"pubmed_authors":["Joe B","Mandal J","Mei X","Tummala R","Kleinhenz A","Aryal S","de la Serna I","Manandhar I","Basrur V","Gunning WT","Chakraborty S","Yeoh BS","Yang T","Mell B","Saha P","Vijay-Kumar M"],"additional_accession":[]},"is_claimable":false,"name":"Epigenetic Histone β-Hydroxybutyrylation Contributes to Renoprotection by β-Hydroxybutyrate in the Dahl Rat.","description":"<h4>Background</h4>Previously, we demonstrated that the ketone body, β-hydroxybutyrate, is a potent antihypertensive and reno-protective metabolite in Dahl Salt-Sensitive rats. However, the mechanism by which β-hydroxybutyrate confers these beneficial effects is understudied. Here we focused on determining whether the reno-protective effect of β-hydroxybutyrate is due to its known ability to epigenetically remodel chromatin via histone β-hydroxybutyrylation.<h4>Methods</h4>We used the same animal protocol previously used for the discovery of the reno-protective effect of β-hydroxybutyrate. Briefly, postweaning, male and female Dahl Salt-Sensitive rats were split into 2 groups and supplemented with or without 1,3-butanediol for 6 weeks. At euthanasia, circulating β-hydroxybutyrate was quant","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-07-16T18:42:34.873Z","creation":"2026-07-11T03:08:21.629Z"},"accession":"S-EPMC12444880","cross_references":{"pubmed":["40726393"],"doi":["10.1161/HYPERTENSIONAHA.125.25251"]}}