{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wittenberg RE"],"funding":["National Institute of Neurological Disorders and Stroke","Chernowitz Medical Research Foundation","NIDA NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","NIDDK NIH HHS","NIMH NIH HHS","National Aeronautics and Space Administration","NIAAA NIH HHS","National Institute of Mental Health","NINDS NIH HHS","National Institutes of Health","National Institute on Drug Abuse"],"pagination":["467-478"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12445159"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["99(6)"],"pubmed_abstract":["<h4>Background</h4>An important yet poorly understood risk factor for opioid use disorder is adolescent nicotine use. We investigated the neural mechanisms underlying this understudied interaction.<h4>Methods</h4>Male and female adolescent mice received 2 weeks of nicotine water (Adol Nic) or plain water (Adol Water). In adulthood, mice underwent 3 morphine tests: conditioned place preference (CPP), locomotor sensitization, and two-bottle choice. Ex vivo ventral tegmental area (VTA) brain slices were assessed via patch clamp for GABA (gamma-aminobutyric acid) and dopamine (DA) neuron responses to morphine. Finally, VTA GABA neurons were chemogenetically inhibited during morphine CPP.<h4>Results</h4>In adulthood, Adol Nic mice showed greater morphine CPP, more choice-based morphine consumpt"],"journal":["Biological psychiatry"],"pubmed_title":["Paradoxical Ventral Tegmental Area GABA Signaling Drives Enhanced Morphine Reward After Adolescent Nicotine."],"pmcid":["PMC12445159"],"funding_grant_id":["F31 DA053111","R37 DA053296","R01 AA026267","R01 NS088555","R01 MH129970","80NSSC21K0814","R01 DK135871"],"pubmed_authors":["Swanson OK","Dani JA","Wolfman SL","Yang K","Yun S","Eisch AJ","Colon LM","Wittenberg RE"],"additional_accession":[]},"is_claimable":false,"name":"Paradoxical Ventral Tegmental Area GABA Signaling Drives Enhanced Morphine Reward After Adolescent Nicotine.","description":"<h4>Background</h4>An important yet poorly understood risk factor for opioid use disorder is adolescent nicotine use. We investigated the neural mechanisms underlying this understudied interaction.<h4>Methods</h4>Male and female adolescent mice received 2 weeks of nicotine water (Adol Nic) or plain water (Adol Water). In adulthood, mice underwent 3 morphine tests: conditioned place preference (CPP), locomotor sensitization, and two-bottle choice. Ex vivo ventral tegmental area (VTA) brain slices were assessed via patch clamp for GABA (gamma-aminobutyric acid) and dopamine (DA) neuron responses to morphine. Finally, VTA GABA neurons were chemogenetically inhibited during morphine CPP.<h4>Results</h4>In adulthood, Adol Nic mice showed greater morphine CPP, more choice-based morphine consumpt","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Mar","modification":"2026-07-16T15:12:45.634Z","creation":"2026-07-09T11:04:35.542Z"},"accession":"S-EPMC12445159","cross_references":{"pubmed":["40571270"],"doi":["10.1016/j.biopsych.2025.05.027"]}}