{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zou Z"],"funding":["Research Cooperation Platform Project of Sino-Japanese Friendship Hospital of Jilin University and Basic Medical School of Jilin University","National Natural Science Foundation of China","Department of Science and Technology of Jilin Province"],"pagination":["e70615"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12445200"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(9)"],"pubmed_abstract":["<h4>Introduction</h4>Ferroptosis is an essential pathophysiological process in cerebral ischemic injury. Activin receptor-interacting protein 1 (ARIP1) is a negative regulator of the activin signaling pathway in neurons.<h4>Objective</h4>This study investigated whether activin A inhibits neuronal ferroptosis and the role of ARIP1 in cerebral ischemic injury.<h4>Methods and results</h4>In this study, activin A increased the viability of primary neurons under conditions of oxygen-glucose deprivation (OGD). Subsequent RNA-sequencing analysis of activin A-treated neurons identified expression of Slc7a11 as the ferroptosis-associated gene with significant upregulation. Next, using the CRISPR/Cas9 system, mice were generated with a heterozygous deficiency of ARIP1 (Arip1<sup>-/+</sup>), and the "],"journal":["CNS neuroscience & therapeutics"],"pubmed_title":["ARIP1 Deficiency Facilitates the Inhibition of Neuronal Ferroptosis in Cerebral Ischemia by Activin A Through SMAD3 and p38 MAPK Signaling."],"pmcid":["PMC12445200"],"funding_grant_id":["81971174","20230505042ZP","81371445","KYXZ2022JC04"],"pubmed_authors":["Liu H","Xie D","Zou Z","Liu Z","Qie X","Zhang Y","Guo C","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"ARIP1 Deficiency Facilitates the Inhibition of Neuronal Ferroptosis in Cerebral Ischemia by Activin A Through SMAD3 and p38 MAPK Signaling.","description":"<h4>Introduction</h4>Ferroptosis is an essential pathophysiological process in cerebral ischemic injury. Activin receptor-interacting protein 1 (ARIP1) is a negative regulator of the activin signaling pathway in neurons.<h4>Objective</h4>This study investigated whether activin A inhibits neuronal ferroptosis and the role of ARIP1 in cerebral ischemic injury.<h4>Methods and results</h4>In this study, activin A increased the viability of primary neurons under conditions of oxygen-glucose deprivation (OGD). Subsequent RNA-sequencing analysis of activin A-treated neurons identified expression of Slc7a11 as the ferroptosis-associated gene with significant upregulation. Next, using the CRISPR/Cas9 system, mice were generated with a heterozygous deficiency of ARIP1 (Arip1<sup>-/+</sup>), and the ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T15:14:52.078Z","creation":"2026-04-29T03:09:00.845Z"},"accession":"S-EPMC12445200","cross_references":{"pubmed":["40965963"],"doi":["10.1111/cns.70615"]}}