{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Boeck M"],"funding":["NEI NIH HHS","NICHD NIH HHS","NHLBI NIH HHS"],"pagination":["107877"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12445345"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["219"],"pubmed_abstract":["Retinopathy of prematurity (ROP) with early vessel loss (Phase I) followed by uncontrolled vessel growth (Phase II) causes visual impairment in premature infants. Although supplementation with omega-3 (n-3) docosahexaenoic acid (DHA) alone shows mixed results in preventing ROP, supplementation with both n-3 DHA and n-6 arachidonic acid (ARA) in early postnatal life reduces severe ROP by 50 % (Mega Donna Mega study). In the Mega Donna Mega study, 146 (72.6 %) of 201 included infants had at least one hyperglycemic episode during the first 14 days of life, which is a strong ROP risk factor. We therefore evaluated the protective effects and mechanisms of combined dietary n-3 DHA and n-6 ARA in a neonatal mouse model of hyperglycemia-induced suppression of retinal vascular development (Phase I "],"journal":["Pharmacological research"],"pubmed_title":["Combined dietary omega-3 and omega-6 fatty acids protect against hyperglycemia-associated retinopathy in neonatal mice."],"pmcid":["PMC12445345"],"funding_grant_id":["R01 EY032492","R01 EY017017","R01 HL149302","R01 HL126901","U54 HD090255","R01 EY030904"],"pubmed_authors":["Hirst V","Kasai T","Neilsen K","Yu M","Wang C","Lee J","Fu Z","Aikawa M","Zeng Y","Boeck M","Lee D","Hellstrom A","Nilsson AK","Yagi H","Pivodic A","Nian S","Singh SA","Chen CT","Bazinet RP","Lundgren P","Smith LE","McCutcheon A"],"additional_accession":[]},"is_claimable":false,"name":"Combined dietary omega-3 and omega-6 fatty acids protect against hyperglycemia-associated retinopathy in neonatal mice.","description":"Retinopathy of prematurity (ROP) with early vessel loss (Phase I) followed by uncontrolled vessel growth (Phase II) causes visual impairment in premature infants. Although supplementation with omega-3 (n-3) docosahexaenoic acid (DHA) alone shows mixed results in preventing ROP, supplementation with both n-3 DHA and n-6 arachidonic acid (ARA) in early postnatal life reduces severe ROP by 50 % (Mega Donna Mega study). In the Mega Donna Mega study, 146 (72.6 %) of 201 included infants had at least one hyperglycemic episode during the first 14 days of life, which is a strong ROP risk factor. We therefore evaluated the protective effects and mechanisms of combined dietary n-3 DHA and n-6 ARA in a neonatal mouse model of hyperglycemia-induced suppression of retinal vascular development (Phase I ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T16:52:11.596Z","creation":"2026-04-29T03:13:15.115Z"},"accession":"S-EPMC12445345","cross_references":{"pubmed":["40706777"],"doi":["10.1016/j.phrs.2025.107877"]}}