biostudies-literatureUnknown5(9)Pantoja-Arevalo LMuscle health has not been thoroughly analyzed in pediatric cystic fibrosis (CF) under elexacaftor/tezacaftor/ivacaftor (ETI) therapy together with exercise interventions in randomized controlled trials (RCTs). The aim of this study will be to determine the effects of a virtual live exercise training intervention on muscle health and cardiorespiratory fitness (CRF) variables in a pediatric population with CF under ETI therapy. The 'FIQMODE' Study (FIQ for CF in Spanish, or fibrosis quística; MOD for modulator therapy; and E for exercise) is a two-arm RCT to evaluate the feasibility and efficacy of a novel exercise intervention to improve the muscle health and quality of life (QoL) of children and adolescents with CF under ETI pharmacological therapies. The exercise group will follow a 16-wCurrent protocolse70202https://www.ebi.ac.uk/biostudies/studies/S-EPMC12445441biostudies-literatureStrength-Oriented Virtual Exercise Training Intervention in Children and Adolescents with Cystic Fibrosis Under CFTR Modulators (the FIQMODE Study): Study Protocol for a Randomized Controlled Trial.PMC12445441Pantoja-Arevalo LLopez-Neyra ASanz-Santiago VSantiago-Dorrego CBarcelo OMorales-Tirado ARamirez-Castillejo CDe Vidania SRubio Alonso MYvert TIturriaga TPerez-Ruiz MQuesada-Gonzalez CGonzalez-Gross MDe Manuel Gomez CRuiz de Valbuena MfalseStrength-Oriented Virtual Exercise Training Intervention in Children and Adolescents with Cystic Fibrosis Under CFTR Modulators (the FIQMODE Study): Study Protocol for a Randomized Controlled Trial.Muscle health has not been thoroughly analyzed in pediatric cystic fibrosis (CF) under elexacaftor/tezacaftor/ivacaftor (ETI) therapy together with exercise interventions in randomized controlled trials (RCTs). The aim of this study will be to determine the effects of a virtual live exercise training intervention on muscle health and cardiorespiratory fitness (CRF) variables in a pediatric population with CF under ETI therapy. The 'FIQMODE' Study (FIQ for CF in Spanish, or fibrosis quística; MOD for modulator therapy; and E for exercise) is a two-arm RCT to evaluate the feasibility and efficacy of a novel exercise intervention to improve the muscle health and quality of life (QoL) of children and adolescents with CF under ETI pharmacological therapies. The exercise group will follow a 16-w2025-01-01T00:00:00Z2025 Sep2026-06-03T17:02:19.829Z2026-05-30T03:06:29.875ZS-EPMC124454414096606810.1002/cpz1.70202