{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xiong J"],"funding":["General Program of National Natural Science Foundation of China","Liaoning Provincial Science and Technology Program","Science and Technology Innovation Fund of Dalian"],"pagination":["e0332698"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12445528"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(9)"],"pubmed_abstract":["Cerebral ischemia-reperfusion injury (CIRI) occurs during the treatment of ischemic stroke when the affected blood vessels are recanalized and the oxygen supply to the brain is restored. Chloride intracellular channel 1 (CLIC1) and the nuclear factor erythroid-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway have been implicated in many neurological disorders. However, the exact mechanism by which CLIC1 contributes to CIRI remains unclear, and its potential role in modulating the Nrf2/HO-1 signaling pathway in CIRI has yet to be explored. We investigated the potential roles of CLIC1 in CIRI using an oxygen and glucose deprivation/reoxygenation (OGD/R) model in HT22 cells. The findings of our study indicated that CLIC1 was high-expressed after OGD/R and had an inhibitory effect on th"],"journal":["PloS one"],"pubmed_title":["CLIC1 down-regulates Nrf2/HO-1 signalling pathway promoting the apoptosis and pyroptosis in OGD/R-treated HT22 cells."],"pmcid":["PMC12445528"],"funding_grant_id":["2021JJ12SN38","82071911","2022-MS-329"],"pubmed_authors":["Xiong J","Wu J","Li S","Yu C","Cao Y","Sun C","Qu X","Chen H","Zhang A"],"additional_accession":[]},"is_claimable":false,"name":"CLIC1 down-regulates Nrf2/HO-1 signalling pathway promoting the apoptosis and pyroptosis in OGD/R-treated HT22 cells.","description":"Cerebral ischemia-reperfusion injury (CIRI) occurs during the treatment of ischemic stroke when the affected blood vessels are recanalized and the oxygen supply to the brain is restored. Chloride intracellular channel 1 (CLIC1) and the nuclear factor erythroid-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway have been implicated in many neurological disorders. However, the exact mechanism by which CLIC1 contributes to CIRI remains unclear, and its potential role in modulating the Nrf2/HO-1 signaling pathway in CIRI has yet to be explored. We investigated the potential roles of CLIC1 in CIRI using an oxygen and glucose deprivation/reoxygenation (OGD/R) model in HT22 cells. The findings of our study indicated that CLIC1 was high-expressed after OGD/R and had an inhibitory effect on th","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-03T14:58:21.435Z","creation":"2026-04-28T03:11:42.585Z"},"accession":"S-EPMC12445528","cross_references":{"pubmed":["40966238"],"doi":["10.1371/journal.pone.0332698"]}}