{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun X"],"funding":["General Logistics Department, People&apos;s Liberation Army","Chongqing Social Science Planning Fund"],"pagination":["e0332816"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12445566"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(9)"],"pubmed_abstract":["<h4>Background</h4>Depression is one of the most burdensome mental disorders. Anhedonia, a core symptom of major depressive disorder (MDD), is characterized by abnormal resting-state reward network (RN). However, it is unclear whether anhedonia symptom and depressive episode share similar resting-state RN mechanism, as well as whether the RN mechanism is a state or trait-like marker of depression. This study aims to clarify the two points by recruitingboth current and remitted depression.<h4>Methods</h4>Using functional Magnetic Resonance Imaging (fMRI) scans, this study observed the resting-state RN function connectivity (with the seed of ventral striatum) in patients with remitted depression (RMD, n = 27) and current depression (n = 30) and 33 normal controls. The low-frequency fluctuati"],"journal":["PloS one"],"pubmed_title":["Reward network mechanism in anhedonia and depression."],"pmcid":["PMC12445566"],"funding_grant_id":["2021HL003","2023NDYB94"],"pubmed_authors":["Chen Z","Jin C","Dai Q","Sun X","Cui C"],"additional_accession":[]},"is_claimable":false,"name":"Reward network mechanism in anhedonia and depression.","description":"<h4>Background</h4>Depression is one of the most burdensome mental disorders. Anhedonia, a core symptom of major depressive disorder (MDD), is characterized by abnormal resting-state reward network (RN). However, it is unclear whether anhedonia symptom and depressive episode share similar resting-state RN mechanism, as well as whether the RN mechanism is a state or trait-like marker of depression. This study aims to clarify the two points by recruitingboth current and remitted depression.<h4>Methods</h4>Using functional Magnetic Resonance Imaging (fMRI) scans, this study observed the resting-state RN function connectivity (with the seed of ventral striatum) in patients with remitted depression (RMD, n = 27) and current depression (n = 30) and 33 normal controls. The low-frequency fluctuati","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-03T15:01:14.105Z","creation":"2026-04-28T03:11:37.049Z"},"accession":"S-EPMC12445566","cross_references":{"pubmed":["40966302"],"doi":["10.1371/journal.pone.0332816"]}}