biostudies-literatureSun XGeneral Logistics Department, People&apos;s Liberation ArmyChongqing Social Science Planning Funde0332816https://www.ebi.ac.uk/biostudies/studies/S-EPMC12445566biostudies-literatureUnknown20(9)<h4>Background</h4>Depression is one of the most burdensome mental disorders. Anhedonia, a core symptom of major depressive disorder (MDD), is characterized by abnormal resting-state reward network (RN). However, it is unclear whether anhedonia symptom and depressive episode share similar resting-state RN mechanism, as well as whether the RN mechanism is a state or trait-like marker of depression. This study aims to clarify the two points by recruitingboth current and remitted depression.<h4>Methods</h4>Using functional Magnetic Resonance Imaging (fMRI) scans, this study observed the resting-state RN function connectivity (with the seed of ventral striatum) in patients with remitted depression (RMD, n = 27) and current depression (n = 30) and 33 normal controls. The low-frequency fluctuatiPloS oneReward network mechanism in anhedonia and depression.PMC124455662021HL0032023NDYB94Chen ZJin CDai QSun XCui CfalseReward network mechanism in anhedonia and depression.<h4>Background</h4>Depression is one of the most burdensome mental disorders. Anhedonia, a core symptom of major depressive disorder (MDD), is characterized by abnormal resting-state reward network (RN). However, it is unclear whether anhedonia symptom and depressive episode share similar resting-state RN mechanism, as well as whether the RN mechanism is a state or trait-like marker of depression. This study aims to clarify the two points by recruitingboth current and remitted depression.<h4>Methods</h4>Using functional Magnetic Resonance Imaging (fMRI) scans, this study observed the resting-state RN function connectivity (with the seed of ventral striatum) in patients with remitted depression (RMD, n = 27) and current depression (n = 30) and 33 normal controls. The low-frequency fluctuati2025-01-01T00:00:00Z20252026-06-03T15:01:14.105Z2026-04-28T03:11:37.049ZS-EPMC124455664096630210.1371/journal.pone.0332816