{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vinckier C"],"funding":["Cancer and Their Family Caregivers","NavCare-EU Intervention for Older People","European Union","Research Foundation Flanders-Fonds Wetenschappelijk Onderzoek","European Health and Digital Executive Agency","EU NAVIGATE","International Pragmatic Randomized Controlled Trial"],"pagination":["oyaf223"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12445657"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(9)"],"pubmed_abstract":["<h4>Background</h4>Older adults with cancer often experience frailty and comorbidities, potentially impacting their quality of life. Knowledge on quality-of-life changes throughout the cancer trajectory is important to set feasible expectations in interventions or trials.<h4>Aim</h4>This systematic review synthesizes existing knowledge on quality-of-life changes in older adults with cancer throughout their illness trajectory and explores potential individual, relational, community, and societal factors associated with these changes.<h4>Method</h4>We systematically searched PubMed, Embase, and PsycINFO. We synthesized characteristics and outcomes of all studies reporting on quality-of-life or well-being changes in people aged 65+ with cancer. We used Bronfenbrenner's Social Ecological Model to categorize associated factors. We followed PRISMA guidelines and registered in PROSPERO (CRD42024566815).<h4>Results</h4>We included 22 studies. Studies varied in characteristics of the cohorts and timing of the measurements and were often lacking clear quality-of-life conceptualizations. All studies used a quantitative design, except 1 mixed-methods study. Eight of 9 studies with follow-up moments of 12 months or more reported stable quality-of-life scores. All 3 studies examining the last year of life found quality-of-life declines. Five other studies reported a decline during treatment; in 4 studies followed by an increase. Comorbidities, older age, and mobility problems were most frequently associated with declining quality of life. Relational, community, and societal level factors were rarely studied.<h4>Conclusion</h4>Despite the methodological heterogeneity between studies, we identified trends in quality-of-life changes across the illness trajectories of older adults with cancer, particularly declining trends during treatment and end-of-life periods and stable trends in long-term follow-up."],"journal":["The oncologist"],"pubmed_title":["Changes in quality of life throughout the illness trajectory of older adults with cancer: a systematic review."],"pmcid":["PMC12445657"],"funding_grant_id":["101057361","12AEO24N"],"pubmed_authors":["Vinckier C","Smets T","de Nooijer K","Van den Block L","Du Cheyne H","Decoster L"],"additional_accession":[]},"is_claimable":false,"name":"Changes in quality of life throughout the illness trajectory of older adults with cancer: a systematic review.","description":"<h4>Background</h4>Older adults with cancer often experience frailty and comorbidities, potentially impacting their quality of life. Knowledge on quality-of-life changes throughout the cancer trajectory is important to set feasible expectations in interventions or trials.<h4>Aim</h4>This systematic review synthesizes existing knowledge on quality-of-life changes in older adults with cancer throughout their illness trajectory and explores potential individual, relational, community, and societal factors associated with these changes.<h4>Method</h4>We systematically searched PubMed, Embase, and PsycINFO. We synthesized characteristics and outcomes of all studies reporting on quality-of-life or well-being changes in people aged 65+ with cancer. We used Bronfenbrenner's Social Ecological Model to categorize associated factors. We followed PRISMA guidelines and registered in PROSPERO (CRD42024566815).<h4>Results</h4>We included 22 studies. Studies varied in characteristics of the cohorts and timing of the measurements and were often lacking clear quality-of-life conceptualizations. All studies used a quantitative design, except 1 mixed-methods study. Eight of 9 studies with follow-up moments of 12 months or more reported stable quality-of-life scores. All 3 studies examining the last year of life found quality-of-life declines. Five other studies reported a decline during treatment; in 4 studies followed by an increase. Comorbidities, older age, and mobility problems were most frequently associated with declining quality of life. Relational, community, and societal level factors were rarely studied.<h4>Conclusion</h4>Despite the methodological heterogeneity between studies, we identified trends in quality-of-life changes across the illness trajectories of older adults with cancer, particularly declining trends during treatment and end-of-life periods and stable trends in long-term follow-up.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T14:29:08.038Z","creation":"2026-04-28T03:11:41.206Z"},"accession":"S-EPMC12445657","cross_references":{"pubmed":["40700604"],"doi":["10.1093/oncolo/oyaf223"]}}