{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["69(10)"],"submitter":["Algodi M"],"pubmed_abstract":["<h4>Background and aims</h4>The optimal perioperative management of patients chronically using renin-angiotensin system inhibitors (RASIs) is still uncertain. This study aims to compare the outcomes of withholding versus continuing RASIs before surgery, focusing on efficacy and safety.<h4>Methods</h4>A systematic review and meta-analysis synthesising evidence from randomised controlled trials (RCTs) obtained from PubMed, CENTRAL, Scopus, and Web of Science until September 2024. Using Stata MP v. 17, we used the fixed-effects model to report dichotomous outcomes by using the risk ratio (RR) with a 95% confidence interval (CI).<h4>Results</h4>Ten RCTs with 3,740 patients were included. There was no statistical difference between both groups regarding the incidence of major adverse cardiac ev"],"journal":["Indian journal of anaesthesia"],"pagination":["984-998"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12445768"],"repository":["biostudies-literature"],"pubmed_title":["Stopping versus continuing renin-angiotensin system inhibitors before surgery: An updated systematic review and meta-analysis of randomised controlled trials."],"pmcid":["PMC12445768"],"pubmed_authors":["Al-Sagban A","Albayyaa M","Hashim HT","Saab O","Al-Obaidi AD","Al-Hemyari B","Algodi M"],"additional_accession":[]},"is_claimable":false,"name":"Stopping versus continuing renin-angiotensin system inhibitors before surgery: An updated systematic review and meta-analysis of randomised controlled trials.","description":"<h4>Background and aims</h4>The optimal perioperative management of patients chronically using renin-angiotensin system inhibitors (RASIs) is still uncertain. This study aims to compare the outcomes of withholding versus continuing RASIs before surgery, focusing on efficacy and safety.<h4>Methods</h4>A systematic review and meta-analysis synthesising evidence from randomised controlled trials (RCTs) obtained from PubMed, CENTRAL, Scopus, and Web of Science until September 2024. Using Stata MP v. 17, we used the fixed-effects model to report dichotomous outcomes by using the risk ratio (RR) with a 95% confidence interval (CI).<h4>Results</h4>Ten RCTs with 3,740 patients were included. There was no statistical difference between both groups regarding the incidence of major adverse cardiac ev","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-05-03T03:21:19.459Z","creation":"2026-05-03T03:12:30.734Z"},"accession":"S-EPMC12445768","cross_references":{"pubmed":["40979762"],"doi":["10.4103/ija.ija_416_25"]}}