biostudies-literatureUnknown69(10)Algodi M<h4>Background and aims</h4>The optimal perioperative management of patients chronically using renin-angiotensin system inhibitors (RASIs) is still uncertain. This study aims to compare the outcomes of withholding versus continuing RASIs before surgery, focusing on efficacy and safety.<h4>Methods</h4>A systematic review and meta-analysis synthesising evidence from randomised controlled trials (RCTs) obtained from PubMed, CENTRAL, Scopus, and Web of Science until September 2024. Using Stata MP v. 17, we used the fixed-effects model to report dichotomous outcomes by using the risk ratio (RR) with a 95% confidence interval (CI).<h4>Results</h4>Ten RCTs with 3,740 patients were included. There was no statistical difference between both groups regarding the incidence of major adverse cardiac evIndian journal of anaesthesia984-998https://www.ebi.ac.uk/biostudies/studies/S-EPMC12445768biostudies-literatureStopping versus continuing renin-angiotensin system inhibitors before surgery: An updated systematic review and meta-analysis of randomised controlled trials.PMC12445768Al-Sagban AAlbayyaa MHashim HTSaab OAl-Obaidi ADAl-Hemyari BAlgodi MfalseStopping versus continuing renin-angiotensin system inhibitors before surgery: An updated systematic review and meta-analysis of randomised controlled trials.<h4>Background and aims</h4>The optimal perioperative management of patients chronically using renin-angiotensin system inhibitors (RASIs) is still uncertain. This study aims to compare the outcomes of withholding versus continuing RASIs before surgery, focusing on efficacy and safety.<h4>Methods</h4>A systematic review and meta-analysis synthesising evidence from randomised controlled trials (RCTs) obtained from PubMed, CENTRAL, Scopus, and Web of Science until September 2024. Using Stata MP v. 17, we used the fixed-effects model to report dichotomous outcomes by using the risk ratio (RR) with a 95% confidence interval (CI).<h4>Results</h4>Ten RCTs with 3,740 patients were included. There was no statistical difference between both groups regarding the incidence of major adverse cardiac ev2025-01-01T00:00:00Z2025 Oct2026-05-03T03:21:19.459Z2026-05-03T03:12:30.734ZS-EPMC124457684097976210.4103/ija.ija_416_25