{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mineiro M"],"funding":["Swiss National Science Foundation"],"pagination":["897-912"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12445815"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["248(2)"],"pubmed_abstract":["Upon perception of insect eggs, Arabidopsis thaliana activates a generic immune response that culminates in cell death (hypersensitive-like response (HR-like)). While this response can subsequently impact egg survival, the molecular mechanisms are poorly understood. Through a genome-wide association study (GWAS), we identified the amino acid-gated calcium channel GLUTAMATE-LIKE RECEPTOR2.7 (GLR2.7) as an important gene controlling the extent of HR-like and accumulation of salicylic acid (SA) in response to egg extract of Pieris brassicae. Analysis of natural polymorphisms showed that two major haplotypes segregate at the species-wide level and suggests that balancing selection acts at this locus. Insect oviposition triggered a long-lasting localized cytosolic calcium accumulation that depe"],"journal":["The New phytologist"],"pubmed_title":["The glutamate receptor-like GLR2.7 modulates insect egg-induced defense responses in Arabidopsis."],"pmcid":["PMC12445815"],"funding_grant_id":["310030_200372"],"pubmed_authors":["Mateo P","Mineiro M","Robert CAM","Gouhier-Darimont C","Reymond P","Groux R"],"additional_accession":[]},"is_claimable":false,"name":"The glutamate receptor-like GLR2.7 modulates insect egg-induced defense responses in Arabidopsis.","description":"Upon perception of insect eggs, Arabidopsis thaliana activates a generic immune response that culminates in cell death (hypersensitive-like response (HR-like)). While this response can subsequently impact egg survival, the molecular mechanisms are poorly understood. Through a genome-wide association study (GWAS), we identified the amino acid-gated calcium channel GLUTAMATE-LIKE RECEPTOR2.7 (GLR2.7) as an important gene controlling the extent of HR-like and accumulation of salicylic acid (SA) in response to egg extract of Pieris brassicae. Analysis of natural polymorphisms showed that two major haplotypes segregate at the species-wide level and suggests that balancing selection acts at this locus. Insect oviposition triggered a long-lasting localized cytosolic calcium accumulation that depe","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-03T15:22:48.997Z","creation":"2026-04-29T03:11:56.694Z"},"accession":"S-EPMC12445815","cross_references":{"pubmed":["40716030"],"doi":["10.1111/nph.70405"]}}