biostudies-literatureMineiro MSwiss National Science Foundation897-912https://www.ebi.ac.uk/biostudies/studies/S-EPMC12445815biostudies-literatureUnknown248(2)Upon perception of insect eggs, Arabidopsis thaliana activates a generic immune response that culminates in cell death (hypersensitive-like response (HR-like)). While this response can subsequently impact egg survival, the molecular mechanisms are poorly understood. Through a genome-wide association study (GWAS), we identified the amino acid-gated calcium channel GLUTAMATE-LIKE RECEPTOR2.7 (GLR2.7) as an important gene controlling the extent of HR-like and accumulation of salicylic acid (SA) in response to egg extract of Pieris brassicae. Analysis of natural polymorphisms showed that two major haplotypes segregate at the species-wide level and suggests that balancing selection acts at this locus. Insect oviposition triggered a long-lasting localized cytosolic calcium accumulation that depeThe New phytologistThe glutamate receptor-like GLR2.7 modulates insect egg-induced defense responses in Arabidopsis.PMC12445815310030_200372Mateo PMineiro MRobert CAMGouhier-Darimont CReymond PGroux RfalseThe glutamate receptor-like GLR2.7 modulates insect egg-induced defense responses in Arabidopsis.Upon perception of insect eggs, Arabidopsis thaliana activates a generic immune response that culminates in cell death (hypersensitive-like response (HR-like)). While this response can subsequently impact egg survival, the molecular mechanisms are poorly understood. Through a genome-wide association study (GWAS), we identified the amino acid-gated calcium channel GLUTAMATE-LIKE RECEPTOR2.7 (GLR2.7) as an important gene controlling the extent of HR-like and accumulation of salicylic acid (SA) in response to egg extract of Pieris brassicae. Analysis of natural polymorphisms showed that two major haplotypes segregate at the species-wide level and suggests that balancing selection acts at this locus. Insect oviposition triggered a long-lasting localized cytosolic calcium accumulation that depe2025-01-01T00:00:00Z2025 Oct2026-06-03T15:22:48.997Z2026-04-29T03:11:56.694ZS-EPMC124458154071603010.1111/nph.70405