biostudies-literatureUnknown4(10 Pt 2)Eligini S<h4>Background</h4>Coronary artery bypass graft (CABG) surgery is performed in patients with complex multivessel coronary artery disease, but long-term graft occlusion remains a major limitation. The immature surfactant protein type-B (proSP-B) has emerged as a predictor of adverse cardiovascular outcomes.<h4>Objectives</h4>The purpose of this study was to examine the relationship between preoperative plasma proSP-B and graft occlusion 18 months post-CABG. The aims were to evaluate whether elevated proSP-B could predict graft occlusion and to assess its predictive value within a multivariable model for long-term graft patency.<h4>Methods</h4>We evaluated proSP-B in relation to graft occlusion in 40 patients with occluded grafts (cases) and 130 patients without occlusions (noncases), with 1JACC. Advances102119https://www.ebi.ac.uk/biostudies/studies/S-EPMC12446526biostudies-literatureImmature Surfactant Protein Type-B Associates With Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting.PMC12446526Andreini DParolari ABanfi CEligini SAgostoni PGianazza EBrocca LVeglia FTremoli EPolvani GPapaianni GGPepi MCavallotti LfalseImmature Surfactant Protein Type-B Associates With Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting.<h4>Background</h4>Coronary artery bypass graft (CABG) surgery is performed in patients with complex multivessel coronary artery disease, but long-term graft occlusion remains a major limitation. The immature surfactant protein type-B (proSP-B) has emerged as a predictor of adverse cardiovascular outcomes.<h4>Objectives</h4>The purpose of this study was to examine the relationship between preoperative plasma proSP-B and graft occlusion 18 months post-CABG. The aims were to evaluate whether elevated proSP-B could predict graft occlusion and to assess its predictive value within a multivariable model for long-term graft patency.<h4>Methods</h4>We evaluated proSP-B in relation to graft occlusion in 40 patients with occluded grafts (cases) and 130 patients without occlusions (noncases), with 12025-01-01T00:00:00Z2025 Sep2026-06-03T15:36:49.121Z2026-05-30T03:07:22.472ZS-EPMC124465264090737710.1016/j.jacadv.2025.102119