{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu J"],"funding":["National Youth Science Foundation Project","Research Funding Project for Returned Overseas Students in Shanxi Province","Discipline Construction Fund of Shanxi University of Chinese Medicine","Research Project of Shanxi Provincial Administration of Traditional Chinese Medicine","Basic Research Project of Shanxi Province","Traditional Chinese Medicine Innovation Team of Shanxi Provincial Administration of Traditional Chinese Medicine","Medical Science and Technology Leading Team of Shanxi Provincial Health Commission","Shanxi University of Chinese Medicine 2022 Science and Technology Innovation Team","Project Proposal for Traditional Chinese Medicine Research by Shanxi Provincial Health Commission in 2022"],"pagination":["e70598"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12446574"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(9)"],"pubmed_abstract":["Background
Multiple sclerosis (MS) is marked by inflammatory demyelination in the central nervous system (CNS), involving diverse glial populations. This pathological process is associated with inflammation and oxidative stress. Proanthocyanidin B2 (PCB2), with its potent antioxidant properties, has been shown to alleviate demyelination in the cuprizone (CPZ) mouse model. It attenuates neuroinflammation and oxidative stress in both the cerebral microenvironment and astrocytes (AS). The xCT/GSH/GPX4 axis is a key regulatory pathway for oxidative stress. Therefore, we hypothesize that PCB2 can alleviate CPZ-induced demyelination by regulating the xCT/GSH/GPX4 axis in AS.Methods
The study utilized forty C57BL/6 mice, randomly allocated into four groups of ten: a control group,"],"journal":["CNS neuroscience & therapeutics"],"pubmed_title":["Proanthocyanidin B2 Alleviates Cuprizone-Induced Demyelination by Regulating the Astrocytic xCT/GSH/GPX4 Axis."],"pmcid":["PMC12446574"],"funding_grant_id":["2024XKJS-02","202303021221162","2020TD05","zyytd2024039","2023ZYYB040","81903596","2022-165","2022ZYYC090","2022TD2006"],"pubmed_authors":["Liu J","Pu M","Zhang ZW","Wang Q","Xiao Y","Zheng LL","Ma CG","Chen Y","Hou YX","Liang YJ","Mao Z"],"additional_accession":[]},"is_claimable":false,"name":"Proanthocyanidin B2 Alleviates Cuprizone-Induced Demyelination by Regulating the Astrocytic xCT/GSH/GPX4 Axis.","description":"Background
Multiple sclerosis (MS) is marked by inflammatory demyelination in the central nervous system (CNS), involving diverse glial populations. This pathological process is associated with inflammation and oxidative stress. Proanthocyanidin B2 (PCB2), with its potent antioxidant properties, has been shown to alleviate demyelination in the cuprizone (CPZ) mouse model. It attenuates neuroinflammation and oxidative stress in both the cerebral microenvironment and astrocytes (AS). The xCT/GSH/GPX4 axis is a key regulatory pathway for oxidative stress. Therefore, we hypothesize that PCB2 can alleviate CPZ-induced demyelination by regulating the xCT/GSH/GPX4 axis in AS.Methods
The study utilized forty C57BL/6 mice, randomly allocated into four groups of ten: a control group,","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-07-15T12:32:45.276Z","creation":"2026-07-04T03:13:24.917Z"},"accession":"S-EPMC12446574","cross_references":{"pubmed":["40968556"],"doi":["10.1111/cns.70598"]}}