{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Li Z"],"pubmed_abstract":["<h4>Objective and methods</h4>Widespread antibiotic misuse has resulted in growing antimicrobial resistance, diminishing the clinical efficacy of existing antibiotics against resistant strains. Therefore, we designed and synthesized a novel pleuromutilin derivative <b>PDP</b>, and its antibacterial activities were evaluated <i>in vitro</i> and <i>in vivo</i>.<h4>Results</h4><b>PDP</b> exhibited potent antibacterial activity against Gram-positive bacteria (MRSA, MRSE, <i>Staphylococcus aureus, Streptococcus agalactiae</i> and <i>Staphylococcus dysgalactiae</i>), demonstrating a remarkably low MIC of 0.008 μg/mL, which was superior to both reference drugs tiamulin and valnemulin. Moreover, compared to tiamulin, it displayed a slower rate of resistance development. Molecular docking results d"],"journal":["Frontiers in pharmacology"],"pagination":["1657973"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12447641"],"repository":["biostudies-literature"],"pubmed_title":["Synthesis and biological activity evaluation of a novel pleuromutilin derivative 22-((2-methyl-1-(1H-pyrrole-2-carboxamido)propan-2-yl)thio)-deoxypleuromutilin."],"pmcid":["PMC12447641"],"pubmed_authors":["Li Z","Li J","Ge W","Qin Z","Bai L","Liu C","Ma D","Xu X"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis and biological activity evaluation of a novel pleuromutilin derivative 22-((2-methyl-1-(1H-pyrrole-2-carboxamido)propan-2-yl)thio)-deoxypleuromutilin.","description":"<h4>Objective and methods</h4>Widespread antibiotic misuse has resulted in growing antimicrobial resistance, diminishing the clinical efficacy of existing antibiotics against resistant strains. Therefore, we designed and synthesized a novel pleuromutilin derivative <b>PDP</b>, and its antibacterial activities were evaluated <i>in vitro</i> and <i>in vivo</i>.<h4>Results</h4><b>PDP</b> exhibited potent antibacterial activity against Gram-positive bacteria (MRSA, MRSE, <i>Staphylococcus aureus, Streptococcus agalactiae</i> and <i>Staphylococcus dysgalactiae</i>), demonstrating a remarkably low MIC of 0.008 μg/mL, which was superior to both reference drugs tiamulin and valnemulin. Moreover, compared to tiamulin, it displayed a slower rate of resistance development. Molecular docking results d","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-03T17:18:13.995Z","creation":"2026-04-29T03:12:59.657Z"},"accession":"S-EPMC12447641","cross_references":{"pubmed":["40978463"],"doi":["10.3389/fphar.2025.1657973"]}}