{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Stolnicu S"],"funding":["National Cancer Institute Division of Cancer Epidemiology and Genetics","National Cancer Institute","NCI NIH HHS","National Institutes of Health"],"pagination":["17-26"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12447657"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["57(1)"],"pubmed_abstract":["The aim of this study was to determine whether the presence and extent of lymphovascular invasion (LVI) is prognostic in surgical stage I cervical squamous cell carcinoma (SCC). All available tumour slides and/or paraffin blocks from 426 patients with stage I cervical SCC treated surgically with curative intent were collected from 18 institutions and retrospectively analysed. Presence and extent of LVI (focal <5 spaces, extensive ≥5 spaces) were assessed on scanning magnification in large haematoxylin and eosin slide sets in 366 cases. Progression-free survival (PFS) was calculated as the time from surgery to first progression or death or last follow-up, whichever occurred first. Overall survival (OS) was defined as the time from surgery to death or last follow-up. Clinicopathological and "],"journal":["Pathology"],"pubmed_title":["Presence and extent of lymphovascular invasion in surgical stage I squamous cell carcinoma of the cervix: a comprehensive, international, multicentre, retrospective clinicopathological study."],"pmcid":["PMC12447657"],"funding_grant_id":["P30 CA008748"],"pubmed_authors":["Ali-Fehmi R","Fadare O","Cibula D","Hoang L","Pesci A","Oliva E","Turashvili G","Ieni A","Felix A","Guerra E","Dundr P","Kiyokawa T","Hodgson A","Mateoiu C","Devins KM","Allison D","Momeni-Boroujeni A","Baiocchi G","Roma A","Lastra RR","Soslow RA","de Brot L","Kheil M","Tessier-Cloutier B","Terinte C","Stolnicu S"],"additional_accession":[]},"is_claimable":false,"name":"Presence and extent of lymphovascular invasion in surgical stage I squamous cell carcinoma of the cervix: a comprehensive, international, multicentre, retrospective clinicopathological study.","description":"The aim of this study was to determine whether the presence and extent of lymphovascular invasion (LVI) is prognostic in surgical stage I cervical squamous cell carcinoma (SCC). All available tumour slides and/or paraffin blocks from 426 patients with stage I cervical SCC treated surgically with curative intent were collected from 18 institutions and retrospectively analysed. Presence and extent of LVI (focal <5 spaces, extensive ≥5 spaces) were assessed on scanning magnification in large haematoxylin and eosin slide sets in 366 cases. Progression-free survival (PFS) was calculated as the time from surgery to first progression or death or last follow-up, whichever occurred first. Overall survival (OS) was defined as the time from surgery to death or last follow-up. Clinicopathological and ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2026-06-14T06:05:40.559Z","creation":"2026-06-14T03:15:14.872Z"},"accession":"S-EPMC12447657","cross_references":{"pubmed":["39477763"],"doi":["10.1016/j.pathol.2024.07.008"]}}