biostudies-literatureStolnicu SNational Cancer Institute Division of Cancer Epidemiology and GeneticsNational Cancer InstituteNCI NIH HHSNational Institutes of Health17-26https://www.ebi.ac.uk/biostudies/studies/S-EPMC12447657biostudies-literatureUnknown57(1)The aim of this study was to determine whether the presence and extent of lymphovascular invasion (LVI) is prognostic in surgical stage I cervical squamous cell carcinoma (SCC). All available tumour slides and/or paraffin blocks from 426 patients with stage I cervical SCC treated surgically with curative intent were collected from 18 institutions and retrospectively analysed. Presence and extent of LVI (focal <5 spaces, extensive ≥5 spaces) were assessed on scanning magnification in large haematoxylin and eosin slide sets in 366 cases. Progression-free survival (PFS) was calculated as the time from surgery to first progression or death or last follow-up, whichever occurred first. Overall survival (OS) was defined as the time from surgery to death or last follow-up. Clinicopathological and PathologyPresence and extent of lymphovascular invasion in surgical stage I squamous cell carcinoma of the cervix: a comprehensive, international, multicentre, retrospective clinicopathological study.PMC12447657P30 CA008748Ali-Fehmi RFadare OCibula DHoang LPesci AOliva ETurashvili GIeni AFelix AGuerra EDundr PKiyokawa THodgson AMateoiu CDevins KMAllison DMomeni-Boroujeni ABaiocchi GRoma ALastra RRSoslow RAde Brot LKheil MTessier-Cloutier BTerinte CStolnicu SfalsePresence and extent of lymphovascular invasion in surgical stage I squamous cell carcinoma of the cervix: a comprehensive, international, multicentre, retrospective clinicopathological study.The aim of this study was to determine whether the presence and extent of lymphovascular invasion (LVI) is prognostic in surgical stage I cervical squamous cell carcinoma (SCC). All available tumour slides and/or paraffin blocks from 426 patients with stage I cervical SCC treated surgically with curative intent were collected from 18 institutions and retrospectively analysed. Presence and extent of LVI (focal <5 spaces, extensive ≥5 spaces) were assessed on scanning magnification in large haematoxylin and eosin slide sets in 366 cases. Progression-free survival (PFS) was calculated as the time from surgery to first progression or death or last follow-up, whichever occurred first. Overall survival (OS) was defined as the time from surgery to death or last follow-up. Clinicopathological and 2025-01-01T00:00:00Z2025 Feb2026-06-14T06:05:40.559Z2026-06-14T03:15:14.872ZS-EPMC124476573947776310.1016/j.pathol.2024.07.008