{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(9)"],"submitter":["Mireles R"],"pubmed_abstract":["Long-chain n-alkane functionalization is relevant for industrial and environmental applications, but it remains a significant challenge due to the inherent stability of their covalent bonds. Biocatalytic approaches offer promising strategies due to their potential for selective, efficient, and environmentally friendly processes. Among the enzyme families known to functionalize long-chain n-alkanes, one iron-binding protein, AlkB, has been characterized. Additionally, two distinct metal-free flavin-dependent enzymes, LadA and AlmA, are presumed to perform this function. Unlike the membrane-bound AlkB, LadA and AlmA are soluble proteins, making them more amenable to engineering and scalable industrial applications. In this study, we attempted to reproduce and optimize the n-alkane monooxygen"],"journal":["PloS one"],"pagination":["e0332702"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12449030"],"repository":["biostudies-literature"],"pubmed_title":["Can flavoprotein monooxygenases functionalize long-chain n-alkanes?"],"pmcid":["PMC12449030"],"pubmed_authors":["Teufel R","Matthews A","Noda-Garcia L","Mireles R"],"additional_accession":[]},"is_claimable":false,"name":"Can flavoprotein monooxygenases functionalize long-chain n-alkanes?","description":"Long-chain n-alkane functionalization is relevant for industrial and environmental applications, but it remains a significant challenge due to the inherent stability of their covalent bonds. Biocatalytic approaches offer promising strategies due to their potential for selective, efficient, and environmentally friendly processes. Among the enzyme families known to functionalize long-chain n-alkanes, one iron-binding protein, AlkB, has been characterized. Additionally, two distinct metal-free flavin-dependent enzymes, LadA and AlmA, are presumed to perform this function. Unlike the membrane-bound AlkB, LadA and AlmA are soluble proteins, making them more amenable to engineering and scalable industrial applications. In this study, we attempted to reproduce and optimize the n-alkane monooxygen","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-03T14:37:02.993Z","creation":"2026-05-29T03:05:09.808Z"},"accession":"S-EPMC12449030","cross_references":{"pubmed":["40971999"],"doi":["10.1371/journal.pone.0332702"]}}