{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(18)"],"submitter":["Jiang C"],"pubmed_abstract":["<h4>Background</h4>Amplification of 11q13 (FGF3/4/19, CCND1) is frequently observed in head and neck squamous cell carcinoma (HNSCC). However, there is a lack of research investigating 11q13 amplification as a prognostic marker for patients with locally advanced (LA) HNSCC who undergo postoperative radiotherapy (PORT).<h4>Materials and methods</h4>This retrospective study included consecutive patients of LA-HNSCC who underwent radical surgical resection and PORT. The 11q13 amplification was tested by next-generation Sequencing (NGS) or fluorescent in situ hybridization (FISH). Propensity score matching (PSM) was used to match the amplification and wild-type groups. Univariate and multivariate analyses were conducted using Kaplan-Meier and Cox regression. Recurrence patterns and phenotypes "],"journal":["Cancer medicine"],"pagination":["e71235"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12449658"],"repository":["biostudies-literature"],"pubmed_title":["Prognosis and Failure Patterns of 11q13 Amplified Local Advanced Squamous Cell Carcinoma of the Head and Neck."],"pmcid":["PMC12449658"],"pubmed_authors":["Ye L","Jiang W","Fu X","Jiang C","Li R","Zhang L","Zhu G","Wang Y","Dou S"],"additional_accession":[]},"is_claimable":false,"name":"Prognosis and Failure Patterns of 11q13 Amplified Local Advanced Squamous Cell Carcinoma of the Head and Neck.","description":"<h4>Background</h4>Amplification of 11q13 (FGF3/4/19, CCND1) is frequently observed in head and neck squamous cell carcinoma (HNSCC). However, there is a lack of research investigating 11q13 amplification as a prognostic marker for patients with locally advanced (LA) HNSCC who undergo postoperative radiotherapy (PORT).<h4>Materials and methods</h4>This retrospective study included consecutive patients of LA-HNSCC who underwent radical surgical resection and PORT. The 11q13 amplification was tested by next-generation Sequencing (NGS) or fluorescent in situ hybridization (FISH). Propensity score matching (PSM) was used to match the amplification and wild-type groups. Univariate and multivariate analyses were conducted using Kaplan-Meier and Cox regression. Recurrence patterns and phenotypes ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T15:32:38.316Z","creation":"2026-06-01T03:06:16.491Z"},"accession":"S-EPMC12449658","cross_references":{"pubmed":["40974176"],"doi":["10.1002/cam4.71235"]}}