{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["66(12)"],"submitter":["Villafuerte-Trisolini C"],"pubmed_abstract":["<h4>Purpose</h4>Lipids are a principal component of drusen and are involved in the pathobiology of age-related macular degeneration (AMD). Nonhuman primates (NHPs) develop macular drusen and may provide insight into circulating or local lipids in AMD.<h4>Methods</h4>We evaluated aged rhesus macaques by fundus photography, optical coherence tomography (OCT), and fundus autofluorescence, as well as measured fasting plasma glucose, total cholesterol, high- and low-density lipoproteins, triglycerides, and apolipoprotein (Apo) A1, B, CIII, and E. Retinal tissues were collected for electron microscopy and immunostained for oil red O, ApoE, and ApoB.<h4>Results</h4>Among 203 adult macaques (mean age 19.1 ± 3.1 years), 25 animals (12.1%) exhibited soft drusen with sub-RPE deposits, while 59 (28.6%"],"journal":["Investigative ophthalmology & visual science"],"pagination":["41"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12449822"],"repository":["biostudies-literature"],"pubmed_title":["Systemic and Local Lipids in Nonhuman Primates With Drusen and Age-Related Maculopathies."],"pmcid":["PMC12449822"],"pubmed_authors":["Raposo AS","Havel P","Farsiu S","Thomasy SM","Roszak K","Graham J","Villafuerte-Trisolini C","Huynh L","Choy K","Gong M","Shen T","Heo J","Yiu G","Le SM","Sin TN"],"additional_accession":[]},"is_claimable":false,"name":"Systemic and Local Lipids in Nonhuman Primates With Drusen and Age-Related Maculopathies.","description":"<h4>Purpose</h4>Lipids are a principal component of drusen and are involved in the pathobiology of age-related macular degeneration (AMD). Nonhuman primates (NHPs) develop macular drusen and may provide insight into circulating or local lipids in AMD.<h4>Methods</h4>We evaluated aged rhesus macaques by fundus photography, optical coherence tomography (OCT), and fundus autofluorescence, as well as measured fasting plasma glucose, total cholesterol, high- and low-density lipoproteins, triglycerides, and apolipoprotein (Apo) A1, B, CIII, and E. Retinal tissues were collected for electron microscopy and immunostained for oil red O, ApoE, and ApoB.<h4>Results</h4>Among 203 adult macaques (mean age 19.1 ± 3.1 years), 25 animals (12.1%) exhibited soft drusen with sub-RPE deposits, while 59 (28.6%","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T15:22:21.891Z","creation":"2026-04-29T03:11:50.692Z"},"accession":"S-EPMC12449822","cross_references":{"pubmed":["40965406"],"doi":["10.1167/iovs.66.12.41"]}}