biostudies-literatureUnknown66(12)Villafuerte-Trisolini C<h4>Purpose</h4>Lipids are a principal component of drusen and are involved in the pathobiology of age-related macular degeneration (AMD). Nonhuman primates (NHPs) develop macular drusen and may provide insight into circulating or local lipids in AMD.<h4>Methods</h4>We evaluated aged rhesus macaques by fundus photography, optical coherence tomography (OCT), and fundus autofluorescence, as well as measured fasting plasma glucose, total cholesterol, high- and low-density lipoproteins, triglycerides, and apolipoprotein (Apo) A1, B, CIII, and E. Retinal tissues were collected for electron microscopy and immunostained for oil red O, ApoE, and ApoB.<h4>Results</h4>Among 203 adult macaques (mean age 19.1 ± 3.1 years), 25 animals (12.1%) exhibited soft drusen with sub-RPE deposits, while 59 (28.6%Investigative ophthalmology & visual science41https://www.ebi.ac.uk/biostudies/studies/S-EPMC12449822biostudies-literatureSystemic and Local Lipids in Nonhuman Primates With Drusen and Age-Related Maculopathies.PMC12449822Raposo ASHavel PFarsiu SThomasy SMRoszak KGraham JVillafuerte-Trisolini CHuynh LChoy KGong MShen THeo JYiu GLe SMSin TNfalseSystemic and Local Lipids in Nonhuman Primates With Drusen and Age-Related Maculopathies.<h4>Purpose</h4>Lipids are a principal component of drusen and are involved in the pathobiology of age-related macular degeneration (AMD). Nonhuman primates (NHPs) develop macular drusen and may provide insight into circulating or local lipids in AMD.<h4>Methods</h4>We evaluated aged rhesus macaques by fundus photography, optical coherence tomography (OCT), and fundus autofluorescence, as well as measured fasting plasma glucose, total cholesterol, high- and low-density lipoproteins, triglycerides, and apolipoprotein (Apo) A1, B, CIII, and E. Retinal tissues were collected for electron microscopy and immunostained for oil red O, ApoE, and ApoB.<h4>Results</h4>Among 203 adult macaques (mean age 19.1 ± 3.1 years), 25 animals (12.1%) exhibited soft drusen with sub-RPE deposits, while 59 (28.6%2025-01-01T00:00:00Z2025 Sep2026-06-03T15:22:21.891Z2026-04-29T03:11:50.692ZS-EPMC124498224096540610.1167/iovs.66.12.41