biostudies-literatureUnknown14(15)Xu M<h4>Background</h4>Previous evidence on sex differences in stroke care and outcomes was limited in sample representativeness and coverage of care indicators. We aim to investigate various indicators of stroke care quality, survival, and functional outcome at discharge between men and women, using a national stroke registry.<h4>Methods</h4>Ten key indicators, representative from across stroke care pathway, were compared between men and women using the Sentinel Stroke National Audit Programme, a national quality register for England, Wales, and Northern Ireland (2013-2023, n=844 970). Multivariable Poisson regression models with robust variance were constructed to estimated adjusted relative risks (ARR). The 1-year adjusted hazard ratios (AHR) of mortality were conducted using adjusted restrJournal of the American Heart Associatione040926https://www.ebi.ac.uk/biostudies/studies/S-EPMC12449931biostudies-literatureSex Differences in Stroke Care and Outcomes: A National Stroke Registry Study.PMC12449931Anwar ICarr HJohnson MJLuxon TMillward SBailey AJangra SMagee MKawafi KXu MFletcher NFisher CSalt DRaghunathan SBorishade OYoung JKitchen JWhite JMorell JRate SNutman KWhite PAttwood AAl Hussayni SHolman EMould KTurner SSims DMiller AHollands SFinnemore CKidson-Petlem KSSNAP Collaboration †Beaumont CRamsey AMcKenna CRamsey DBoston LQuarterman CRashed KVincent HKrishnamoorthy SWest SRossiter CHolt GFrance JFill PChatterjee KMir RJacob SHilton DWitham RThiru SFowler LTone ENewbury JWilde CDavis ECrane CAlmond CLowrey VMalkin SEllis TFarag RTyler RWinterburn EKennedy AKanneganti SSEllis LHolley BEllis HEspasandin MGadapa NKValley AEveson DMistry DDe Canha JJohnson JJohnson KJohnson LBrowne JAtkinson CFlaherty JStevens JDouiri AParrington HGiraldo LChaston NBetsworth SHeath DEpps STheobalds SBennett ACherian SDima SMcfadden DCadman CBayliss DBayliss CGriffiths BDean DElghenzai SOkin RSweeting NGriffiths EHastings YHunter SOrme SMaliK GHornby JHargroves DHulbert ASlade PRagab SHunter AMathieson PRaza SStewart CBurn MMaendl LSteward VVahidassr DUtting NAlam SMahmood SHeathcote SCrozier SCook CBaht HSouthern LOrlikowski MWalters CMabuti JLloyd CThomas CGriffiths MAMason JThomas AGumbley GThomas JAshman LBass DThomas NGeorgy ECross JRiley LBroomhead PNagaratnam KShaw LMitchell KMcMullen EAmlani SO'Connell MDLHalstead GNhanga EAlcorn MTomkins KEady CRoberts CCox KClarke BMajmudar NLakin TBlack TRavi PHowarth EBlake MKettlewell AWatson CDodd AGaul AMSudlow MGaneshram KSingh RKeeney AHussain MWise JParwaz TUmmatt NAjibade OCorrick PWebster JCrew FHaines JLogan AWebster CShastri KTunesi RHorsey GWootton ACooke LMMaddula MDavidson JHealy RStone APenniall LHarrison TMahon CByrne TDodds AAilsa HMahadevan MWhitbread HStanley KRawlinson LMarshall JHussain FSmith GGearhart JKhan MShah BChua LNair AWright PMaguire SReading SWilliams NBracken JStergiou PCork EPie JMaguire HSukys USutton PJames MKwan JPatel RStephens-Cross ZDe Campos CSivakumar RJames VHussian IWright JSibson RMunshi SPretorius LWiggam IConnolly CWilliams VHellier KWilliams SKelly TKaswala JJillings ALuder RJones AKelly JCrichton HHall CDriver EWolfe CPhilip SBay HMazzucco SLevens KHoll LBowman MElmarimi APancholi MRana PPalanichamy RWyatt NHills-Garner MCutts RElmamoun SHunt AHill AUmasankar UJoy RBaz SMacLeod JKeegan BParker CLyddon HMohapatra SSekhar AJones KTownsend NJones VLovegrove ABarnes ECastle EClarke AMMarsh RHolden GScott JMorris SSands LJackson KHbid YMagrath MPasco KPalanisamy SDownie RChembala JKubie JJelley DBAhmad STClark JEmery RWilson JHughes TClark DButler SKane IMartin LWillcoxson PWebber AHughes GColeman SRitchie JAlwis LCannon MPathansali RYeardley VBhargava MDavies PHorton KRehman HPearce LNash TLee SAndrews AThomson LKirthivasan RO'Leary KMartin CODhar HEdwards ALee CSalmeron AMProeschel HPout VJopling GBahk AAdams CCoupland GNi HHolland NNambi RShenton LRichard BFrith FShekhar RSimister RAngior DAllen LUgharadar SPanju ZSimon GVu THaji-Coll MPrice EEstabrook NFreemantle LCarpenter MBireh KBrotheridge SBarker KBhat YSoe TVlahovic IHolmes CBarratt LGilpin JChadwick NKandiah ASakkariyas HKirkland MBeattie ACowey ABerry DStimpson KJenkinson SMisra AShale MASommerville PLong MPower MEdlin GStorey ABroscombe CHinds KJewson RLorena NHagan GOMattinson KBagguley JBull CAujla SEddy ALechler VRobinson KBoggis LWalley GCampbell SRose DQuirke JYuvaraj RPWarke KMcBride SSchmitt JDurward GfalseSex Differences in Stroke Care and Outcomes: A National Stroke Registry Study.<h4>Background</h4>Previous evidence on sex differences in stroke care and outcomes was limited in sample representativeness and coverage of care indicators. We aim to investigate various indicators of stroke care quality, survival, and functional outcome at discharge between men and women, using a national stroke registry.<h4>Methods</h4>Ten key indicators, representative from across stroke care pathway, were compared between men and women using the Sentinel Stroke National Audit Programme, a national quality register for England, Wales, and Northern Ireland (2013-2023, n=844 970). Multivariable Poisson regression models with robust variance were constructed to estimated adjusted relative risks (ARR). The 1-year adjusted hazard ratios (AHR) of mortality were conducted using adjusted restr2025-01-01T00:00:00Z2025 Aug2026-06-03T15:24:24.34Z2026-04-29T03:12:03.631ZS-EPMC124499314067357310.1161/JAHA.124.040926